额颞叶变性治疗的研究进展

Research progress of the treatment on frontotemporal lobar degeneration

额颞叶变性(FTLD)以进行性的精神行为异常、执行功能障碍和/(或)语言损害为特征,其在临床表现、病理学和遗传学方面具有异质性给治疗带来了挑战。目前临床对额颞叶变性的治疗仍以对症治疗为主,在药物治疗的基础上辅助非药物干预措施。随着对额颞叶变性病因和发病机制理解的深入,涌现出多种潜在的对因治疗靶点及药物研究新方向。本文综述近年相关治疗研究进展。

Frontotemporal lobar degeneration(FTLD) is characterized the features of progressive psychological and behavioral abnormalities, executive dysfunction and/or language impairment. Due to the heterogeneity of clinical symptom, pathological and genetics, the treatment of FTLD still is a challenge. At present, therapeutic options for FTLD are mainly symptomatic therapy, which are on the basis of pharmacological interventions assisted with non-pharmacological management. However, as the further understanding on FTLD etiology and pathogenesis, many potential therapeutic targets and new directions for drug research have been developed in recent years. This review describes the development of drug therapy for FTLD.