舒肝解郁胶囊对老年心血管病患者伴发焦虑情绪的疗效观察

Efficacy of Shugan Jieyu capsule on elderly cardiovascular disease patients with anxiety emotion

目的探讨舒肝解郁胶囊对老年心血管病患者伴发焦虑情绪的治疗效果。方法将88例伴有焦虑情绪的老年心血管病患者随机分为两组,观察组45例,对照组43例。观察组接受舒肝解郁胶囊治疗,对照组接受帕罗西汀治疗。疗效评定采用汉密尔顿焦虑量表(HAMA),主观幸福感评定采用费城老年中心(PGC)信心量表,同时采用治疗中需处理的不良反应症状量表(TESS)评定不良反应。结果观察组和对照组的有效率分别为88.4%和94.9%,差异无统计学意义(P>0.05)。两组HAMA量表评分均较治疗前有所降低,差异具有统计学意义(P<0.05),且治疗2周对照组评分下降较观察组更为显著,差异具有统计学意义(P<0.05)。PGC量表比较:两组治疗8周PGC量表总分及各项因子得分均较治疗前明显改善,差异具有统计学意义(P<0.05),观察组在总分、激越因子、孤独与不满因子方面的改善相比对照组更为显著,差异具有统计学意义(P<0.05)。观察组和对照组的不良反应发生率分别为6.98%和44.19%,差异具有统计学意义(P<0.05)。结论舒肝解郁胶囊对老年心血管病患者伴发焦虑情绪的治疗效果与帕罗西汀疗效相当,但其不良反应较小,且更利于改善老年患者的主观幸福感,值得临床推广。

Objective To investigate the efficacy of Shugan Jieyu capsule on elderly cardiovascular disease patients with anxiety emotion. Methods A total of 88 cases elderly cardiovascular disease patients with anxiety emotion were randomly divided into observation group(45 cases) and control group(43 cases). The observation group was treated with Shugan Jieyu capsule, and the control group was treated with paroxetine. The efficacy was assessed by the Hamilton Anxiety(HAMA) scale, and the subjective sense of happiness was assessed by the Philadelphia Geriatric Center(PGC) confidence scale. The adverse reactions were assessed by treatment emergent symptoms scale(TESS). Results The efficacy of observation group and control group were 88.4% and 94.9% respectively, which had no significant differences(P>0.05). The HAMA scale scores of the two groups were both lower than before treatment, the differences were significant(P<0.05). After 2 weeks treatment, the HAMA scale score in control group was decreased more than that in observation group, the difference was significant(P<0.05). After 8 weeks treatment, the PGC scale scores in both groups were improved significantly compared with those before treatment, the differences were significant(P<0.05). Compared with the control group, the total score, agitation factor, loneliness and dissatisfaction factor in observation group were improved significantly(P<0.05). The adverse reactions rates in observation group and control group were 6.98% and 44.19% respectively, and the difference was significant(P<0.05). Conclusion The efficacy of Shugan Jieyu capsule on elderly cardiovascular disease patients with anxiety emotion is equivalent to paroxetine, but it has less adverse reactions. Shugan Jieyu capsule is more conductive to improve the subjective sense of happiness of elderly patients, and worthy to promote in clinical.