黄芪桂枝五物汤加味治疗肺脾气虚型变应性鼻炎的疗效观察

Curative effect of modified Huangqi Guizhi Wuwu decoction on allergic rhinitis patients with lung-spleen qi deficiency

目的观察黄芪桂枝五物汤加味治疗肺脾气虚型变应性鼻炎的临床疗效。方法选取于我院就诊的肺脾气虚型变应性鼻炎患者120例,随机分为治疗组(n=60)和对照组(n=60),治疗组采用黄芪桂枝五物汤加味治疗,对照组采用氯雷他定片治疗,10 d为1个疗程,连续治疗2个疗程,比较两组患者治疗前后血清炎症因子水平和症状改善情况,评估疗效并观察不良反应。结果治疗组总有效率为95.00%,显著优于对照组的76.67%,差异有统计学意义(P<0.05);与治疗前比较,治疗组和对照组治疗后症状和体征计分、IL-6和IL-8水平均显著降低,且治疗组症状和体征计分、IL-6和IL-8水平降低较对照组更显著,差异有统计学意义(P<0.05);治疗组不良反应发生率为3.33%,对照组不良反应发生率为28.33%,差异有统计学意义(P<0.05)。结论黄芪桂枝五物汤加味治疗肺脾气虚型变应性鼻炎效果良好,值得临床推广应用。

Objective To observe the curative effect of modified Huangqi Guizhi Wuwu decoction on allergic rhinitis patients with lung-spleen qi deficiency. Methods A total of 120 cases allergic rhinitis patients with lung-spleen qi deficiency in our hospital were selected and randomly divided into treatment group and control group(n=60). The treatment group was treated with modified Huangqi Guizhi Wuwu decoction and the control group was treated with loratadine tablets. The treatment courses of both groups were lasted 20 days. The serum levels of inflammatory cytokines and the improvement of symptoms were compared between the two groups before and after treatment. The curative effect and adverse reactions were evaluated. Results The total effect rate in the treatment group(95.00%) was obviously better than that in the control group(76.67%, P<0.05). Compared with before treatment, the symptoms and signs score, IL-6 and IL-8 levels were significantly lower after treatment in both groups, and the above indexes in treatment group were improved more obviously than those in control group(P<0.05). The incidence of adverse reactions in treatment group was 3.33%, and in control group was 28.33%, the difference was statistically significant(P<0.05). Conclusion Modified Huangqi Guizhi Wuwu decoction has good curative effect on allergic rhinitis patients with lung-spleen qi deficiency.