化疗药物诱导性周围神经病变研究进展

Advances in chemotherapy-induced peripheral neurotoxicity

化疗药物导致的严重神经毒性反应目前已得到日益重视,临床称之为化疗诱导性周围神经病变(CIPN)。CIPN是肿瘤药物治疗过程中剂量限制性毒性反应之一。本文主要综述传统化疗药物如紫杉烷类化合物、铂类化疗药物、长春花碱类药物、舒拉明钠及沙利度胺等导致的CIPN的临床特点,介绍化疗新药埃坡霉素及蛋白酶体抑制剂的临床应用等。

Severe neurotoxicity induced by chemotherapeutic drugs has been paid more and more attention,and it is clinically called chemotherapy-related peripheral neuropathy(CIPN).CIPN is actually one of the dose-limiting adverse reactions in the course of cancer drug treatment.This article reviews the clinical characteristics of CIPN induced by traditional chemotherapeutics such as taxanes,platinum chemotherapeutics,vinblastines,suramin and thalidomide(TLD).This article introduces the clinical application of new chemotherapeutic drugs epothilone and proteasome inhibitors.