乳腺假血管瘤样间质增生的影像特征与病理表现

Pseudoangiomatous stromal hyperplasia of the breast: Radiological-pathological correlation

乳腺假血管瘤样间质增生(PASH)为一种良性间质细胞增生,属于肌纤维母细胞增生范畴。PASH常发生于绝经前及绝经后使用激素替代治疗的女性,需与低度恶性血管肉瘤、叶状肿瘤及纤维腺瘤鉴别。乳腺X线摄影、B超及核医学诊断PASH价值有限,但在乳腺MRI不同序列上PASH具有一定特点。对于疑诊PASH的病人,分析比较影像表现与穿刺活检病理表现是否一致非常重要。对PASH的临床表现、病理学特点及影像表现等予以综述。

Pseudoangiomatous stromal hyperplasia(PASH)of the breast is defined as benign hyperplasia of stromal cells,which belongs to the spectrum of myofibroblasts proliferation.It is more common in premenopausal women and postmenopausal women received hormone replacement therapy,and has to be distinguished with low-grade angiosarcoma,phyllodes tumors(PTs),and fibroadenoma in breast.Mammography,ultrasound,and nuclear medicine have limitations in making a defective diagnosis of PASH.However,some specific features of PASH can be identified by various sequences of breast magnetic resonance imaging(MRI).For a patient with suspected PASH,it is significantly important to evaluate the consistency between the preoperative radiological findings and histopathologic findings obtained from core needle biopsy specimens(CNBS).The clinical,pathological and imaging features of PASH were reviewed in this study.