糖胺聚糖化学交换饱和转移成像对软骨成分的定量研究进展

The application of MR gagCEST in quantitative assessment of articular cartilage

关节软骨进行性退变是骨关节炎(OA)主要特点,而软骨基质中糖胺聚糖(GAG)的过度降解和丢失是软骨退变中最早出现的代谢变化。常规影像检查对其不敏感,发现时OA多已到晚期且不可逆。GAG化学交换饱和转移成像(MR gagCEST)作为一种最新软骨成分定量成像技术,能实现对软骨GAG成分无创、准确的定量,在OA早期诊断和治疗监测方面具有良好应用前景。对MR gagCEST技术的原理、优缺点及在OA中的临床应用进行综述。

Osteoarthritis(OA)is characterized by progressive degeneration of articular cartilage while the excessive degradation and loss of glycosaminoglycan(GAG)is the earliest histological change in cartilage degeneration.Conventional imaging techniques are not sensitive to the change.When OA was diagnosed by the conventional image techniques,it already had developed to late and irreversible stage.MR glycosaminoglycan chemical exchange saturation transfer(gagCEST)as a novel quantitative MR technique provides a noninvasive and accurate measurement of GAG content in cartilage,it has bright application prospect in early diagnosis and treatment monitoring of OA.This review emphasizes on the mechanism,advantages and weaknesses of MR gagCEST technology,and the clinical application in evaluation of OA were also included.