Gd-EOB-DTPA增强MRI T_1 mapping技术在肝脏疾病的应用进展

The application of Gd-EOB-DTPA-enhanced MRI T_1 mapping and its research progresses in hepatic diseases

T_1 mapping成像是定量分析组织T_1值的方法,主要包括Look-Locker(LL)序列、改良的Look-Locker反转恢复序列(MOLLI)及可变多翻转角成像技术。近年来,基于Gd-EOB-DTPA的T_1 mapping成像广泛应用于肝脏。根据注射对比剂前后肝实质的T_1变化,不仅能用于对肝脏损伤程度、肝纤维化分期、肝硬化病人肝储备功能的评估,而且对肝脏局灶性病变的鉴别、肝细胞肝癌分化程度的预测也有一定的价值。就Gd-EOB-DTPA增强MRI T_1 mapping技术在肝脏疾病中的应用现状及研究进展予以综述。

T1 mapping technique is a method to quantitatively analyze T1 of tissue.It includes Look-Locker,modified Look-Locker IR(MOLLI)and variable flip angle sequences,et al.In recent years,T1 mapping based on Gd-EOB-DTPA enhancement was widely used in liver exams.According to the changes of T1 before and after the contrast injection,T1 mapping can not only evaluate the degree of liver injury,stage liver fibrosis,and estimate liver reserve function,but also distinguish liver focal lesions and predict the degree of differentiation of hepatocellular carcinoma.We reviewed the current application of Gd-EOB-DTPA-enhanced MRI T1 mapping and its research progresses in liver diseases.