MCV、MCH检测在地中海贫血筛查中的应用研究

The value of MCV,MCH in the screening of thalassemia

目的探讨红细胞平均体积(MCV)、平均红细胞血红蛋白浓度(MCH)等指标在地中海贫血(简称:地贫)筛查中的应用价值。方法选择进行了MCV、MCH血液学表型筛查的受试者共603例,所有受试者均进行地贫基因检测。以地贫基因检测结果为参比标准,计算MCV和MCH单项或联合检测结果的灵敏度、特异性、准确性、阳性预测值及阴性预测值。结果 MCV、MCH单项检测地贫的灵敏度及特异性分别为91.2%和76.1%,91.2%和70.7%。MCV、MCH平行联合及系列联合检测地贫的灵敏度及特异性分别为94.8%和61.4%,88.4%和75.6%。结论 MCV、MCH单项指标检测地贫均具有较高的灵敏度。MCV、MCH平行联合筛查能提高地贫检测的灵敏度,可广泛应用于地贫的筛查。

Objective To evaluate the value of the tests of mean corpuscular volume (MCV ) ,mean corpuscular hemoglobin (MCH) in the screening of thalassemia .Methods 603 cases were performed MCV and MCH tests and gene detection of thalasse-mia .The results of gene detection were used as reference standard .The sensitivity ,specificity ,accuracy ,positive predictive value and negative predictive value of single or combined results of MCV ,MCH tests were calculated .Results The sensitivity and specificity of single MCV test were 91 .2% and 76 .1% ,single MCH test were 91 .2% and 70 .7% .The sensitivity and specificity of parallel combined tests of MCV and MCH were 94 .8% and 61 .4% ,serial combined tests of MCV and MCH were 88 .4% and 75 .6% .Con-clusion The sensitivity of single MCV or MCH test in the screening of thalassemia is high .Parallel combined tests of MCV and MCH can improve the sensitivity ,and will be widely used in the in the screening of thalassemia .