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Th17细胞和调节性T细胞与自身免疫性肝病的关系 被引量：2

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摘要 Th17细胞和调节性T细胞(Treg细胞)是近年来免疫学研究的热点,二者之间的关系密切而又复杂。在正常的生理情况下,Th17/Treg细胞保持平衡,维持机体的免疫稳定;而在某些病理情况下,这种平衡被打破,从而导致多种疾病的发生、发展。现就Th17细胞和Treg细胞的功能及其与自身免疫性肝病的关系进行综述。1 Treg早在20世纪70年代。
作者 王兰 杨瑞宁 张丽 杨帆
机构地区 中国人民解放军第八一医院检验科
出处 《国际检验医学杂志》 CAS 2014年第8期1022-1023,1088,共3页 International Journal of Laboratory Medicine
关键词 TH17细胞 调节性T细胞 自身免疫
分类号 R392 [医药卫生—免疫学]
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参考文献8

  • 1Moritz Peiseler,Marcial Sebode,Bj?rn Franke,Frederike Wortmann,Dorothee Schwinge,Alexander Quaas,Udo Baron,Sven Olek,Christiane Wiegard,Ansgar W. Lohse,Christina Weiler-Normann,Christoph Schramm,Johannes Herkel.FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency[J].Journal of Hepatology.2012(1)
  • 2Daniela Fenoglio,Francesca Bernuzzi,Florinda Battaglia,Alessia Parodi,Francesca Kalli,Simone Negrini,Raffaele De Palma,Pietro Invernizzi,Gilberto Filaci.Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases[J].Autoimmunity Reviews.2012(2)
  • 3Acharya, Mridu,Mukhopadhyay, Subhankar,Pa?dassi, Helena,Jamil, Tahseen,Chow, Camille,Kissler, Stephan,Stuart, Lynda M,Hynes, Richard O,Lacy-Hulbert, Adam.[alpha]v Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice[J].Journal of Clinical Investigation.2010(12)
  • 4Ruth Y.Z. Lan,Thucydides L. Salunga,Koichi Tsuneyama,Zhe-Xiong Lian,Guo-Xiang Yang,Willy Hsu,Yuki Moritoki,Aftab A. Ansari,Claudia Kemper,Jeff Price,John P. Atkinson,Ross L. Coppel,M. Eric Gershwin.Hepatic IL-17 responses in human and murine primary biliary cirrhosis[J].Journal of Autoimmunity.2008(1)
  • 5Francesca Bernuzzi,Daniela Fenoglio,Florinda Battaglia,Marco Fravega,M. Eric Gershwin,Francesco Indiveri,Aftab A. Ansari,Mauro Podda,Pietro Invernizzi,Gilberto Filaci.Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis[J].Journal of Autoimmunity.2010(3)
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  • 7Arian Laurence,Shoba Amarnath,Jacopo Mariotti,Yong Chan Kim,Jason Foley,Michael Eckhaus,John J. O’Shea,Daniel H. Fowler.STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease[J].Immunity.2012(2)
  • 8Daniela Fenoglio,Florinda Battaglia,Alessia Parodi,Silvia Stringara,Simone Negrini,Nicoletta Panico,Marta Rizzi,Francesca Kalli,Giuseppina Conteduca,Massimo Ghio,Raffaele De Palma,Francesco Indiveri,Gilberto Filaci.Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis[J].Clinical Immunology.2011(3)

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国际检验医学杂志
2014年 第8期

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