高胆红素血症早产儿心肌酶谱检测及其意义

Detection and significance of myocardial enzyme spectrum in premature infants with hyperbilirubinemia

目的探讨高胆红素血症早产儿心肌酶谱变化及临床意义。方法对90例高胆红素血症早产儿的心肌酶谱[天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)]测定结果进行分析,并与对照组27例早产儿作比较。结果高胆红素血症早产儿心肌酶谱均较对照组高,但仅CK-MB升高(P<0.05);心酶阳性发生率55.56%(50/90)明显高于对照组7.41%(2/27),差异有统计学意义(P<0.01)。结论早产儿高胆红素血症可致心肌损害,发生率高。对高胆红素血症早产儿应常规测定心肌酶谱,以指导临床治疗。

Objective To investigate the changes and clinical significance of myocardial enzyme spectrum in the premature in-fants with hyperbilirubinemia .Methods The myocardial enzymes spectrum (AST ,CK ,CK-MB) in 90 premature infants with hy-perbilirubinemia were tested and the detection results were analyzed .Then their comparison with the control group consisting of 27 premature infants was performed .Results The detection results of myocardial enzymes spectrum in the hyperbilirubinemia prema-ture infants were higher than those in the control group ,but only the increase of CK-MB had statistical significance (P<0 .05);the positive incidence rate of the myocardial enzymes in the hyperbilirubinemia premature infants was 55 .56% (50/90) ,which was ob-viously higher than 7 .41% (2/27) in the control group ,the difference had statistical significance (P<0 .01) .Conclusion Hyperbil-irubinemia in premature infants can cause the myocardial damage and has the high incidence rate .The myocardial enzyme spectrum should be routinely detected for guiding the clinical treatment in the premature infants with hyperbilirubinemia .