急性脑梗死患者3项指标的变化研究

Study on the changes of three indicators in patients with acute cerebral infarction

目的探讨同型半胱氨酸(Hcy)、N-末端脑钠肽前体(NT-proBNP)和超敏C反应蛋白(hs-CRP)在急性脑梗死患者梗死面积大小和病程进展情况中的变化。方法对该院2012~2014年收治的80例急性脑梗死患者(研究组)和80例健康体检者(对照组)的血清中Hcy、NT-proBNP和hs-CRP水平进行比较。结果研究组患者血清中Hcy、NT-proBNP和hs-CRP的水平明显高于对照组,差异有统计学意义(P<0.05);其中研究组患者中大面积梗死亚组患者血清中Hcy、NT-proBNP和hs-CRP的水平明显高于小面积梗死亚组,差异有统计学意义(P<0.05)。结论 Hcy、NT-proBNP和hs-CRP三者的联合检测可作为脑梗死面积大小和病程进展情况的监测指标。

Objective To investigate the changes of homocysteine(Hcy) ,N-terminal pro-brain natriuretic peptide(NT-proBNP) and high sensitive C reactive protein(hs-CRP) changes in different area of infarction size and disease progression patients with acute cerebral infarction .Methods From 2012 to 2014 ,the levels of Hcy ,NT-proBNP and hs-CRP were analyzed and compared in a total of 80 patients with acute cerebral infarction(study group) and 80 healthy subjects(control group) .Results The contents of Hcy , NT-proBNP and hs-CRP in the study group were significant higher than those of the control group ,the differences had statistical significance(P<0 .05) .The contents of Hcy ,NT-proBNP and hs-CRP in patients with large area cerebral infarction were significant higher than those in small size cerebral infarction patients ,the differences had statistical significance(P<0 .05) .Conclusion The combined detection of Hcy ,NT-proBNP and hs-CRP could be used as indicators for monitoring cerebral infarction size and disease progress .