联合检测C反应蛋白和中性粒细胞在烧伤感染患者中的临床意义

Clinical significance of combined detection of C reactive protein and neutrophils in burn infection patients

目的探讨烧伤患者外周血中性粒细胞百分比(Neu%)和C反应蛋白(CRP)水平对烧伤感染患者早期诊断的意义。方法 2013年8月至2014年5月该院烧伤整形科住院的烧伤患者84例,轻度、中度及重度烧伤各28例。根据创面感染检查结果将患者分为感染组64例和对照组20例。入院24~48h内清晨空腹采取患者外周血2mL用于白细胞(WBC)、Neu%和CRP的检测,并进行比较。结果 84份标本中66份CRP升高(78.6%),43份WBC升高(51.2%),57份Neu%升高(67.9%)。感染组、对照组WBC差异无统计学意义(P>0.05),Neu%、CRP差异均有统计学意义(P<0.05)。轻度、中度及重度烧伤患者WBC水平间差异无统计学意义(P>0.05),Neu%及CRP间两两比较,差异均有统计学意义(P<0.05)。结论 Neu%、CRP可反映烧伤患者有无感染,并随着烧伤程度的增加而升高,CRP联合Neu%检测在烧伤患者感染与烧伤程度判断上比CRP联合WBC计数更敏感。

Objective To investigate the level of the peripheral blood percentage of neutrophils(Neu% ) and C reactive protein (CRP) in the early diagnosis of burn infection .Methods A total of 84 burn infection patients were collected from August 2013 to May 2014 ,28 cases with minor burns ,28 cases with moderate burns and 28 cases with severe burns .According to test results of wound infection ,they were divided into infected group with 64 cases and control group with 20 patients .Two milliliter peripheral blood samples were collected and used to measure the WBC ,CRP ,and Neu% .Results In the 84 patients ,66 cases with elevated CRP(78 .6% ) ,43 cases with elevated WBC(51 .2% ) and 57 cases with Neu% (67 .9% ) .The WBC levels in the infected group and control group had no significant different(P>0 .05) ,but there were significant differences on the levels of Neu% and CRP(P<0 .05) .WBC of mild ,moderate and severe burn patients had no significant differences(P>0 .05) ,but there were significant differ-ences on the levels of Neu% and CRP(P<0 .05) .Conclusion Neu% ,CRP might reflect the presence or absence of infection in burn patients ,and also increased with the burn degree .The combined detection of CRP and Neu% is more sensitive than the com-bined detection of CRP and WBC .