同型半胱氨酸、叶酸、维生素B_(12)、血清铁蛋白水平与脑梗死的关系

Correlation study on serum homocysteine,folic acid,vitamin B_(12),ferritin levels And cerebral infarction

目的探讨同型半胱氨酸（Hcy）、叶酸、维生素B12、血清铁蛋白（SF）水平与脑梗死的相关性,以期为脑梗死的防治提供新方法。方法选择2012年4月至2014年11月就诊于该院神经内科因缺血性脑血管病住院患者48例（脑梗死组）,并随机选择同期老年健康体检者30例作为健康对照组,两组研究对象性别、年龄比较差异均无统计学意义（P>0.05）,排除其他系统疾病者。患者入院后2472h内进行头颅CT或磁共振成像（MRI）等相关辅助检查后明确脑梗死诊断。所有患者用化学发光法和放射免疫法进行血清Hcy、叶酸、维生素B12、SF检测并应用SPSS17.0统计软件进行数据分析。比较Hcy、叶酸、维生素B12、SF水平与脑梗死的相关性。结果脑梗死组患者血清Hcy、SF水平高于健康对照组,叶酸、维生素B12水平低于健康对照组,差异均有统计学意义（P<0.05）。不同程度脑梗死组患者血清Hcy、叶酸、维生素B12、SF水平比较差异也有统计学意义（P<0.05）。结论检测脑梗死患者血清Hcy、SF、叶酸、维生素B12均有重要的临床价值。

Objective To investigate the correlation between serum homocysteine（Hcy）,folic Acid,vitamin B12,ferritin levels and cerebral infarction,and provide a new way for prevention and treatment of cerebral infarction.Methods Forty-eight hospitalized patients with ischemic cerebrovascular disease who were in the neurology ward department of the hospital from April 2012 to November 2014 were enrolled in the study as cerebral infarction group.Meanwhile,30 healthy elderly patients were recruited randomly as a healthy control group during the same period.There was no significant difference in sex and age between the two groups.People with other diseases were excluded.Hospitalized patients were diagnosed within 24-72 hours and received CT and MRI scan and other related auxiliary examination after being admitted to hospital.All these patients underwent plasma Hcy,folic acid,vitamin B12,ferritin level tests which were determined by using chemiluminescence and radioimmunoassay.SPSS17.0statistical software was used for statistical analysis,and the correlation between Hcy,folic acid,vitamin B12,ferritin and cerebral infarction were analyzed.Results The plasma Hcy and ferritin levels in cerebral infarction group were higher than those in control group,and the difference is significant（P<0.05）.Meanwhile,folic acid,vitamin B12 levels in cerebral infarction group were lower than those in control group and the difference was significant（P<0.05）.There were significant differences in levels of Hcy,folic acid,vitamin B12,ferritin between groups of different cerebral infarction levels.Conclusion Detections of serum Hcy,folic acid,vitamin B12 and ferritin could be of important clinical value in cerebral infarction.