普洱市小儿TORCH感染流行病学调查

Epidemiological investigation on TORCH infection of children in Pu′er

目的对云南省普洱市小儿TORCH感染情况进行流行病学调查,为小儿TORCH感染的防治提供参考。方法选取2014年1~12月于该院就诊的1 194例患儿,并分为5个年龄组。采用酶联免疫吸附试验(ELISA)检测患儿血清中TORCH特异性免疫球蛋白M(IgM)、免疫球蛋白G(IgG)抗体,分析比较TORCH特异性抗体阳性率和TORCH感染率。结果患儿TORCH特异性抗体IgM阳性率明显低于IgG,IgM阳性率为0.00%~3.10%,IgG阳性率为10.13%~82.24%,TORCH总感染率为96.98%;各年龄组单项TORCH感染率及TORCH总感染率比较,差异均无统计学意义(P>0.05);5个年龄组间各单项感染率分布比较,差异有统计学意义(P<0.05);不同季节TORCH感染率及各单项感染率分布比较,差异均无统计学意义(P>0.05)。结论该地区小儿TORCH感染以CMV为主,其次为RV和HSV,TOX感染少见;TORCH感染率无明显季节性差异,且各年龄小儿TORCH感染率无明显差异。

Objective To make an epidemiological investigation on TORCH infection in children in Pu′er city of Yunnan province,in order to provide references for the prevention and treatment of TORCH infection in children.Methods A total of 1 194 children treated at this hospital from January to December 2014 were selected and divided into five age groups.Serum TORCH specific IgM and IgG antibodies were detected by using enzyme-linked immunosorbent assay(ELISA)and the positive rate of TORCH specific antibody and TORCH infection rate were comparatively analysed.Results The positive rate of TORCH specific IgM antibody was significantly lower than that of IgG.The range of positive rate of IgM was 0.00%-3.10%,and that of IgG was10.13%-82.24%.The total infection rate of TORCH was 96.98%.There were no significant differences in the infection rate of single item of TORCH or the total TORCH infection rate among the five different age groups(P>0.05).The distribution of infection rate of single item of TORCH among the five age groups was statistically significantly different(P<0.05).There was no significant difference in the infection rate of TORCH or the distribution of infection rate of single item of TORCH among different seasons(P>0.05).Conclusion Children with TORCH infection in this area mainly are infected by CMV,followed with RV and HSV infections,while TOX infection is uncommon.There are no obvious differences in different seasons and children in different age groups.