玉林市无偿献血者ALT异常与HBV、HCV检测结果的相关性分析

Analysis of the correlation between ALT abnormality and HBV and HCV test results of unpaid blood donors in Yulin City

目的分析无偿献血者血液检测结果中丙氨酸氨基转移酶(ALT)异常与乙型肝炎病毒表面抗原(HBsAg)和丙型肝炎病毒抗体(抗-HCV)阳性结果的相关性,并探讨升高的ALT与肝炎病毒感染之间的相关性,并讨论ALT作为血液筛查计划的必要性。方法对2014年1月至2018年6月玉林市259 408名献血者血液中HBsAg、抗-HCV和ALT的检测结果进行分析,并进行相关分析。结果来自259 408名献血者的253 644份样本ALT结果正常,其中1 190份为HBsAg阳性,抗-HCV阳性者1 053份,核酸检测HBV DNA反应性558份,HCV RNA反应性2份;ALT试验的异常结果为5 764份,其中27份为HBsAg阳性,28份为抗-HCV阳性,核酸检测12份HBV DNA反应性,1份HCV RNA反应性;肝炎标志物阳性的献血者中ALT异常率为6.91%,肝炎标志物阴性的献血者ALT异常率为2.18%。结论 HBsAg与抗-HCV阳性结果和ALT异常结果之间存在相关性,ALT异常与乙型和丙型肝炎病毒感染之间不存在相关性。

Objective To analyze the correlation between alanine aminotransferase(ALT)abnormality and hepatitis B surface antigen(HBsAg)and hepatitis C virus antibody(anti-HCV)positive results in blood test of unpaid blood donors and to explore the correlation between elevated ALT and hepatitis virus infection,and to discuss the necessity of ALT as a blood screening program.Methods The detection results of HBsAg,antiHCV and ALT in blood of 259 408 blood donors in Yulin city From January 2014 to June 2018 were analyzed and relevant analysis was carried out.Results 253 644 samples from 259 408 blood donors showed normal ALT results,including 1 190 HBsAg-positive,1 053 anti-HCV-positive,558 HBV DNA-reactive and 2 HCV RNA-reactive.The abnormal results of ALT test were 5 764,of which 27 were HBsAg-positive,28 were antiHCV-positive,12 were HBV DNA-reactive and 1 was HCV RNA-reactive.The abnormal rate of ALT was6.91%in positive donors and 2.18%in hepatitis marker negative donors.Conclusion There was a correlation between HBsAg and anti-HCV positive results and ALT abnormal results.There was no correlation between ALT abnormality and hepatitis B and C virus infection.