胆道闭锁早期诊断的研究进展

Research progress on early diagnosis of biliary atresia

胆道闭锁(BA)是以肝内外胆管进行性纤维化为特征的小儿外科常见严重疾病,如能在早期明确诊断并且施行手术可显著改善患儿预后,否则预后大多不良,因此胆道闭锁的早期诊断尤为重要。术中胆道造影是诊断BA的金标准,但是创伤性较大,目前仍然需要非损伤性的、特异性和敏感性高的指标来筛查诊断BA。本文将从血液、尿液来源的实验室标记物、粪便比色卡和超声检查进行综述。

Biliary atresia(BA)is a common and serious pediatric surgical disease characterized by progressive fibrosis of the intrahepatic and extrahepatic bile ducts.If the diagnosis can be confirmed at an early stage,surgery can significantly improve the prognosis of the children,otherwise the prognosis is often poor.Therefore,the early diagnosis of biliary atresia is particularly important.Intraoperative cholangiography is the gold standard for the diagnosis of BA,but it is more traumatic.Currently,non-invasive,highly specific and sensitive indicators are still needed to screen the diagnosis of BA.In this paper,laboratory markers from blood and urine sources,stool color card and ultrasonography were reviewed.