慢性肝病和原发性肝癌患者血清白细胞介素-8水平及其意义

The level of IL-8 in the serum of patients suffering from chronic hepatic diseases and primary hepatocellular carci- noma

目的 探讨IL-8在慢性肝病和原发性肝癌发病机理中的作用及与临床变化的关系。方法 对住院治疗的80例各型肝病患者和14例健康人抽取静脉血5ml,分离血清并置于-40℃之中,采用ELISA法对血清进行IL-8检测。结果 不同类型肝病患者血清中IL-8水平差异均有显著性。慢性病毒性肝炎重型IL-8水平为(75.80±33.39)μg/L,原发性肝癌IL-8水平为(89.54±13.24)μg/L,与对照组比较t值分别为10.48、4.01,P<0.01。结论 血清IL-8水平的升高与各类肝病患者病情轻重及预后有密切的关系。在慢性病毒性肝炎和原发性肝癌患者血清中,IL-8水平越高,病情越重,预后越差,病死率越高。

Objective To explore the relation between the pathogenesis and IL-8 level in the chronic hepatic disease and primary hepatocellular carcinoma. Methods 5 ml venous blood was with drawn from 80 hospitaliged patients with different types of hepatic diseases and 14 heathy people. The serum was separated from the blood and then kept at -40'C, and finally detected for IL-8 by ELISA. Results There was an obvious difference among the IL-8 level in the serum from different types of hepatic disease patients. The IL-8 level was 75.80 ug/L+33.39 ug/L in chronic virus hepatitis and it was 89.54 ug/L+ 13.24 ng/L for primary hepatoma patients (t=10.48 and 4.01, respectively, P<0.01, as compared with control group). Conclusions There is a close relation between the level of IL-8 in serum and the state of illness. For patients with chronic hepatic diseases and primary hepatocellular carcinoma, the higher the IL-8 level is, the more serious the patients' condition, the worse the prognosis, and the higher the death rate would be.