薏苡仁油注射液和超液化碘油介入治疗大鼠肝癌的研究

Interventional therapy combining Seed of Job's-stears with lipiodol for hepatoma-bearing rats

目的 研究薏苡仁油注射液+超液化碘油介入治疗肝癌的疗效。方法 复制大鼠移植性肝癌模型,用大鼠肝动脉灌注给药方法,以化疗药、超液化碘油作对照,评价薏苡仁油作为介入药物治疗大鼠肝癌的疗效。结果 单用薏苡仁油与单用碘油肿瘤增殖率分别为13.89％、14.05％,肿瘤生长抑制率分别为38.10％和37.49％、薏苡仁油+碘油组肿瘤增殖率和生长抑制率分别为3.36％、85.03％,优于薏苡仁油组和碘油组(P<0.01),但与丝裂霉素(MMC)+碘油组之间无明显差异,生存时间亦较其他各组显著延长(P<0.01或P<0.05)。结论 经肝动脉灌注薏苡仁油+碘油对大鼠肝肿瘤的生长有较好的抑制作用,疗效与MMC+碘油相仿,优与单纯薏苡仁油及碘油组。对大鼠的生存时间也有明显的延长,优于单纯薏苡仁油、碘油及MMC+碘油组。

Objective To study the effect of the interventional therapy of hepatoma-bearing rat by Seed of Job's-stears (SJS) injection combining with lipiodol. Methods To evaluate the effect of SJS as a medicament which can be used in interventional therapy, we repeated the hepatoma-bearing rats, and treated them by interventional therapy with SJS referring to the method which Lindel set up, comparing its effect to which of chemical medicines and lipiodol. Results SJS or lipiodol alone had an inhibiting effect to liver cancer. The tumor growth rates were 13.89%, 14.05%, and the tumor inhibiting rates reached 38.10%, 37.49%. The curative effect of the SJS/lipiodol group was the best, and its growth rate and inhibiting rate were 3.36% and 85.03%, respectively better than the SJS group and lipiodol group (P<0.01). There was no statistically significant difference between the effect of the SJS/lipiodol group and the mitomycin/lipiodol group. The survival period of SJS/lipiodol group was longer than the rest groups (P<0.01 or P<0.05). Conclusions The interventional therapy by SJS/lipiodol has obvious inhibitory effect on the growth of hepatoma-bearing rats, which is similar to that of MMC/ lipiodol. This inhibiting effect is better than that of the SJS or lipiodol group. SJS/lipiodol can prolong the survival period of hepatoma-bearing rats obviously, and this effect is better than that of single lipiodol, SJS or MMC/lipiodol.