疏肝解郁胶囊联合艾司西酞普兰应用于老年躯体疾病伴焦虑抑郁患者的效果及对治疗依从性的影响

Effect of Shugan Jieyu Capsule combined with escitalopram on elderly physical illness patients with anxiety/depression and its effect on treatment compliance

目的探讨艾司西酞普兰联合疏肝解郁胶囊对躯体疾病伴焦虑抑郁患者的效果。方法抽签法将我院2016年10月～2018年4月收治的113例躯体疾病伴焦虑抑郁患者分为2组,常规治疗基础上,西药组56例予艾司西酞普兰,联合组57例加服疏肝解郁胶囊,连用2月,对比两组总有效率、神经因子水平及依从性。结果联合组2月末总有效率、5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)血清水平及检查、治疗、服药和康复锻炼依从性高于西药组,治疗2w、1月、2月末汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分及不良反应发生率低于西药组(P<0.05)。结论疏肝解郁胶囊与艾司西酞普兰联合可改善老年躯体疾病焦虑抑郁患者神经因子水平,安全有效,患者依从性较高。

Objective To investigate the effect of escitalopram combined with Shugan Jieyu capsule on elderly physical illness patients with anxiety and depression. Methods A total of 113 physical illness patients with anxiety and depression from October 2016 to April 2018 were divided into two groups. On the basis treatment,56 patients in the western medicine group were given escitalopram and 57 in the combined group use Shugan Jieyu Capsule,the total effective rate,neurological factor level and compliance were compared after 2 months. Results After 2 month of treatment,the total effective rate,5-HT,NE,DA serum levels and examination,treatment,medication and rehabilitation exercise compliance were higher than the western medicine group. The HAMA and HAMD scores at the end of 2 w,1 month and 2 month,the adverse reactions occurred rate were lower than the western medicine group(P<0.05).Conclusion Shugan Jieyu Capsule combined with escitalopram can improve the patients,s neurological factors level saftly and effectively,patient compliance is high.