广泛性焦虑障碍患者血清炎性因子水平分析

Serum inflammatory factor level and significance in patients with generalized anxiety disorder

目的研究广泛性焦虑障碍患者血清炎性因子水平及意义。方法选取我院2016年4月~2017年4月收治的66例广泛性焦虑障碍患者作为作为观察组,另外选择66名体检健康的志愿者作为对照组。两组清晨空腹抽取外周静脉血,检测C-反应蛋白(CRP)、白细胞介素-1α(IL-1α)、白细胞介素-6(IL-6)、白细胞介素-12(IL-12)、干扰素-γ(INF-γ)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)各项指标,另外通过相关性分析广泛性焦虑障碍患者血清炎性因子与广泛性焦虑评分(GAD-7)、状态焦虑评分(SAI)及特质焦虑评分(TAI)的关系。结果观察组CRP、IL-1α、IL-6、IL-12、INF-γ、GM-CSF水平与GAD-7、SAI、TAI评分显著高于对照组,差异有统计学意义(P<0.05);广泛性焦虑障碍患者血清炎性因子CRP、IL-1α、IL-6、IL-12、INF-γ、GM-CSF与GAD-7、SAI、TAI呈正相关,r分别为0.259~0.711、0.283~0.533、0.357~0.703,差异有统计学意义(P<0.05)。结论广泛性焦虑障碍患者相对于正常人血清炎症因子水平较高,且炎症因子水平上升与焦虑障碍严重程度相关,因此临床诊疗过程中应密切关注患者血清炎性因子水平。

Objective To study the level and significance of serum inflammatory factors in patients with generalized anxiety disorder.Methods 66 patients with generalized anxiety disorder admitted to our hospital from April 2016 to April 2017 were included in the study as observation group,and 66 healthy volunteers were selected as control group.In the morning on an empty stomach,both groups took a peripheral venous blood and detected the C-reactive protein(CRP)and interleukin 1 alpha(IL-1α),interleukin 6(IL-6),interleukin 12(IL-12),interferon-γ(INF-γ),granulocyte macrophage colony stimulating factor(GM-CSF)the indicators.In addition,the relationship between serum inflammatory factors and generalized anxiety score(GAD-7),state anxiety score(SAI)and trait anxiety score(TAI)was analyzed by correlation analysis.Results The CRP,IL-1α,IL-6,IL-12,INF-γ,GM-CSF level and GAD-7,SAI,TAI scores in observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05);The serum inflammatory factors CRP,IL-1α,IL-6,IL-12,INF-γ,GM-CSF were positively correlated with GAD-7,SAI and TAI,r were 0.259-0.711,0.283-0.533 and 0.357-0.703,respectively,with statistical significance(P<0.05).Conclusion Compared with normal people,patients with generalized anxiety disorder have higher serum inflammatory factor levels,and the increase of inflammatory factor levels is related to the severity of anxiety disorder.Therefore,patients’serum inflammatory factor levels should be closely monitored in the clinical diagnosis and treatment process.