有机磷化合物蛋白质加合物作为生物标志物的研究进展

Protein adducts to organophosphorus compounds as biomarkers:research advances

长期低剂量接触有机磷化合物会引起迟发性神经疾病,严重时可诱变致癌甚至死亡。预防和处理有机磷化合物引起的中毒、判断中毒程度及评估治疗效果,需要及时、准确地检测有机磷化合物。其中最有效的方式是对其体内生物标志物进行检测。本文简要介绍了有机磷化合物及其中毒机制,介绍了蛋白质加合物的研究现状,着重概括了有机磷化合物和白蛋白的加合位点和加合机制,尤其是近年来新发现的加合位点和靶向蛋白。并在此基础上指出了有机磷化合物蛋白质加合物作为生物标志物的发展方向。

Long-term exposure to organophosphorus compounds can lead to delayed neuropathy,which can cause cancer and even death in severe cases. Prevention of organophosphorus compounds poisoning,judging the degree of poisoning and evaluating the therapeutic effect require timely and accurate detection of organophosphorus compounds. The most effective way is to detect biomarkers of organophosphorus compounds in the body. In this report an overview of the biomarkers currently available for detection of organophosphorus compounds is presented. We briefly introduce the organophosphorus compounds and their toxicity mechanism,the research status of protein adducts,especially the newly discovered residue numbers. The advantages and disadvantages of several biomarkers are compared,and the development directions of biomarkers are also addressed.