高血压病患者中超重/肥胖与血压负荷及血压变异的关系

The relation between overload and variability of blood pressure and overweight or obesity in patients with essential hypertension

目的 探讨超重和肥胖高血压病患者与血压变异性关系。方法 191例原发性高血压患者根据体重指数 (BMI)分为正常组、超重组、肥胖组 ,采用 2 4h动态血压检测方法探讨血压负荷及血压变异的特征。结果 BMI增加血压负荷和血压变异性指数均增加 ,与正常组相比超重组和肥胖组夜间收缩压变异 (nSBPSD)增加 14 .10 %、夜间舒张压变异 (nDBPSD)增加 13.15 %、夜间平均动脉压变异 (nMAPSD)增加 15 .92 % ,肥胖组增加更明显 ,分别为 2 0 .0 6 %、17.92 %、2 1.6 3% ;但这种血压变异性的差异仅表现在男性。结论 超重和肥胖的高血压病患者不仅加重血压负荷 ,而且使血压变异性增加 ;这种血压变异性增加只见于男性病人 ,且出现在夜间。

Objective To investigate the relationship between blood pressure variability, overweight or obesity in patients with essential hypertensive. Methods A hundred ninety one patients with essential hypertension were divided into three groups: normal,overwight and obesity according to body mass index (BMI). The characteristies of the variability of 24 hour ambulatory blood pressure monitoring (ABPM) in three groups were compared. Results Blood pressure overload and variability increased parallel with the increase of BMI. In overweight group, the variabilities of systolic blood pressure at night (nSBPSD) increased 14.10 %, the variabilities of diastolic blood pressure at night (nDBPSD) increased 13.15 % and the variabilities of mean arterial pressure at night (nMAPSD) increased 15.92 % respectively. In obesity group, the above three variabilities increased more significantly (compared to normal group P < 0.05 0.01 ). However, increases of the three blood pressure variabilities were observed only in the male patients. Conclusions The overwight or obesity increased the blood pressure overload and variabilities in patients with essential hypertension. The increases of blood pressure variabilities were observed only in male patients and at night.