地高辛联合福辛普利治疗老年高血压心力衰竭的疗效观察

Clinical study on digoxin combined with fosinopril in treatment of elderly hypertensive patients with heart failure

目的探讨地高辛片联合福辛普利片治疗老年高血压心力衰竭的临床疗效。方法选取2016年9月—2017年10月武汉市第五医院心内科收治的老年高血压心力衰竭患者82例,依据治疗方法的不同分为对照组和治疗组,每组各41例。对照组口服福辛普利钠片,初始剂量为10 mg/次,依据患者耐受性、血压、心率等情况逐渐增加剂量至40 mg/次,1次/d。治疗组在对照组治疗的基础上口服地高辛片,0.125～0.25 mg/次,1次/d。两组患者均连续治疗30 d。观察两组的临床疗效,比较两组的心功能指标。结果治疗后,对照组和治疗组的总有效率分别为78.05%、92.68%,两组比较差异有统计学意义(P<0.05)。治疗后,两组左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)显著降低,左心室射血分数(LVEF)显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组心功能指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论地高辛片联合福辛普利片治疗老年高血压心力衰竭具有较好的临床疗效,可改善患者心功能指标,安全性较好,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Digoxin Tablets combined with Fosinopril Sodium Tablets in treatment of elderly hypertensive patients with heart failure. Methods Elderly hypertensive patients(82 cases) with heart failure in the Fifth Hospital of Wuhan from September 2016 to October 2017 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were po administered with Fosinopril Sodium Tablets, starting dosage 10 mg/time, gradually increased the dosage to 40 mg/time according to patient tolerance, blood pressure, heart rate and so on, once daily. Patients in the treatment group were po administered with Digoxin Tablets on the basis of the control group, 0.125 — 0.25 mg/time, once daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacies were evaluated, and the cardiac function indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.05% and 92.68%, respectively, and there was difference between two groups(P < 0.05). After treatment, the LVEDD and LVESD in two groups were significantly decreased, but the LVEF in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the cardiac function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Digoxin Tablets combined with Fosinopril Sodium Tablets has clinical curative effect in treatment of elderly hypertensive patients with heart failure, can improve the cardiac function indexes, with good safety, which has a certain clinical application value.