小儿金翘颗粒联合克林霉素治疗小儿急性扁桃体炎的临床研究

Clinical study on Xiaoer Jinqiao Granules combined with clindamycin in treatment of acute tonsillitis in children

目的观察小儿金翘颗粒联合盐酸克林霉素棕榈酸酯干混悬剂治疗小儿急性扁桃体炎的有效性和安全性。方法选取2014年6月—2017年6月在漯河市中心医院治疗的120例急性扁桃体炎患儿作为研究对象,所有患儿按照入院先后顺序分成对照组和治疗组,每组各60例。对照组患儿温水冲服盐酸克林霉素棕榈酸酯干混悬剂,1袋/次,3次/d;治疗组患者在对照组治疗的基础上开水冲服小儿金翘颗粒,5～7岁儿童7.5 g/次,3次/d;8～10岁儿童7.5 g/次,4次/d;11～12岁儿童10 g/次,3次/d。两组患儿连续治疗1周。观察两组患者的临床疗效,同时比较两组治疗前后的症状积分、主观生活质量问卷(ISLQ)评分、视觉模拟评分法(VAS)、炎性指标水平和不良反应情况。结果治疗后,治疗组的总有效率为96.67%,显著高于对照组的85.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者症状积分、ISLQ评分和VAS评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组症状积分、ISLQ评分和VAS评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清降钙素原(PCT)、白细胞介素-6(IL-6)和C反应蛋白(CRP)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组炎性指标水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗期间,对照组和治疗组的不良反应发生率分别为13.33%、3.33%,两组比较差异具有统计学意义(P<0.05)。结论小儿金翘颗粒联合盐酸克林霉素棕榈酸酯干混悬剂治疗小儿急性扁桃体炎疗效显著,可显著改善患儿体内炎症水平,安全性高,具有一定的临床推广应用价值。

Objective To observe the efficacy and safety of Xiaoer Jinqiao Granules combined with Clindamycin Palmitate Hydrochloride for suspension in treatment of acute tonsillitis in children. Methods Children(120 cases) with acute tonsillitis in Luohe Central Hospital from June 2014 to June 2017 were randomly divided into control and treatment groups according to the order of admission, and each group had 60 cases. Children in the control group were po administered with Clindamycin Palmitate Hydrochloride for suspension with warm water, 1 bag/time, three times daily. Children in the treatment group were po administered with Xiaoer Jinqiao Granules on the basis of the control group, 7.5 g/time for children aged 5 — 7 years, three times daily, 7.5 g/time for children aged 8 — 10 years, four times daily, 10 g/time for children aged 11 — 12 years, three times daily. Children in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the symptom scores, ISLQ scores, VAS, inflammatory index levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 96.67%, which was significantly higher than 85.00% in the control group, and there were differences between two groups(P < 0.05). After treatment, the symptom scores, ISLQ scores, and VAS in two groups were significantly decreased, and there were differences in the same group(P < 0.05). And the symptom scores, ISLQ scores, and VAS in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of PCT, IL-6, and CRP in two groups were significantly decreased, and there were differences in the same group(P < 0.05). And the inflammatory index levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). The incidence of adverse reactions in the control and treatment groups were 13.33% and 3.33%, respectively, and there were differences between two groups(P < 0.05). Conclusion Xiaoer Jinqiao Granules combined with Clindamycin Palmitate Hydrochloride for suspension has good effect in treatment of acute tonsillitis in children, can significantly improve the inflammation level, with high safety, which has a certain clinical application value.