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复合凝乳酶胶囊联合多潘立酮治疗儿童功能性消化不良的临床研究 被引量:26

Clinical study on Gastropylor Complex Capsules combined with domperidone in treatment of functional dyspepsia in children
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摘要 目的探讨复合凝乳酶胶囊联合多潘立酮治疗儿童功能性消化不良的临床效果。方法选取2016年7月—2017年7月河南科技大学第一附属医院收治的功能性消化不良患儿80例,随机分成对照组(40例)和治疗组(40例)。对照组餐前30 min口服多潘立酮混悬液,4~6岁5 mL/次,7~9岁7 mL/次,10~14岁9 mL/次,3次/d。治疗组在对照组基础上餐后30 min口服复合凝乳酶胶囊,4~6岁1粒/次,7~14岁2粒/次,3次/d。两组均连续治疗2周。观察两组患者临床疗效,同时比较治疗前后两组患者主要症状情况、胃动力学参数水平、胃电节律异常情况和胃肠激素水平。结果治疗后,对照组和治疗组临床总有效率分别为85.0%和97.5%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组餐后饱胀、早饱、嗳气发生率均显著降低(P<0.05),且治疗组比对照组下降更显著(P<0.05)。治疗后,两组胃排空时间均显著缩短(P<0.05),胃窦收缩幅度(CA)、收缩次数(CF)值均显著增大(P<0.05),且治疗组胃动力学参数比对照组改善更显著(P<0.05)。治疗后,两组餐前和餐后胃电节律异常率均显著下降(P<0.05),且治疗组患者胃电节律异常率比对照组降低更明显(P<0.05)。治疗后,两组患者血浆胃动素(MLT)、胃泌素(GAS)浓度均显著升高(P<0.05),且治疗组患者血浆MLT和GAS浓度明显高于对照组(P<0.05)。结论复合凝乳酶胶囊联合多潘立酮治疗儿童功能性消化不良,可明显消除消化不良症状,改善胃肠动力,调节胃肠激素分泌。 Objective To investigate the clinical effect of Gastropylor Complex Capsules combined with domperidone in treatment of functional dyspepsia in children. Methods Children(80 cases) with functional dyspepsia in the First Affiliated Hospital of Henan University of Science and Technology from July 2016 to July 2018 were randomly divided into control(40 cases) and treatment(40 cases) groups. Children in the control group were po administered with Gastropylor Complex Capsules 30 min before meals, 5 mL/time for 4 — 6 years old children, 7 mL/time for 7 — 9 years, 9 mL/time for 10 — 14 years, three times daily. Children in the treatment group were po administered with Domperidone Suspension on the basis of the control group 30 min before meals, 1 grain/time for 4 —6 years, 2 grains/time for 7 — 14 years, three times daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the occurrence of main symptoms, gastric dynamics parameters, gastric electric rhythm abnormalities, and the gastrointestinal hormone levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 85.0% and 97.5%, respectively, and there were differences between two groups(P < 0.05). After treatment, the incidence of postprandial bloating, early satiety, belching in two groups was significantly decreased(P < 0.05), and the occurrence of main symptoms in the treatment group was significantly lower than that in the control group(P < 0.05). After treatment, the gastric emptying time in two groups was significantly shortened(P < 0.05), but the CA and CF levels of gastric antrum were significantly increased(P < 0.05), and these gastric dynamics parameters in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the abnormal rate of gastric electrical rhythm before and after meals in two groups was significantly decreased(P < 0.05), and which in the treatment group was significantly lower than that in the control group(P < 0.05). After treatment, the plasma MLT and GAS concentration in two groups was significantly increased(P < 0.05), and the hormones in the treatment group were significantly higher than those in the control group(P < 0.05). Conclusion Gastropylor Complex Capsules combined with domperidone in treatment of functional dyspepsia in children can obviously eliminate the indigestion symptoms, improve gastrointestinal motility and regulate gastrointestinal hormone secretion.
作者 刘友红 焦贝蓓 LIU You-hong;JIAO Bei-bei(Department of Pediatrics,Kaiyuan District of the First Affiliated Hospital of Henan University of Science&Technology,Luoyang 471000,China)
出处 《现代药物与临床》 CAS 2019年第2期401-405,共5页 Drugs & Clinic
关键词 复合凝乳酶胶囊 多潘立酮混悬液 儿童功能性消化不良 胃肠动力 胃电节律 胃肠激素 胃动素 胃泌素 Gastropylor Complex Capsules Domperidone Suspension children with functional dyspepsia gastrointestinal motility, gastric electrical rhythm gastrointestinal hormones MLT GAS
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