阿魏酸抗抑郁作用机制的研究进展

Research progress on antidepressant mechanism of ferulic acid

抑郁症是一种多因素疾病,是一种严重影响人类生活的情绪障碍。由于一线药物的低缓解率与疗效滞后,迫切需要开发治疗抑郁症的新型药物。在各种天然成分中,多酚具有抗氧化、增强免疫调节和抗抑郁样作用引起了许多研究者的关注。阿魏酸是当归、升麻和川芎等中药中存在的酚类化合物,易于代谢并能够穿过血脑屏障进入海马。研究表明阿魏酸的抗抑郁作用涉及神经营养系统、单胺能神经系统、抗炎、抗氧化、以及NMDAR受体拮抗作用。主要对阿魏酸的抗抑郁研究进行综述,为进一步探索阿魏酸的抗抑郁机制提供参考。

Depression is a multi-factor disease, and is a serious impact on human life emotional disorders. Because the low remission rate and curative effect of first-line drugs lag behind, it is urgent to develop new drugs to treat depression. Among various natural ingredients, polyphenols have antioxidant, immunomodulatory, and antidepressant-like effects that have attracted the attention of many researchers. Ferulic acid is a phenolic compound found in traditional Chinese medicines such as Angelica, Cimicifuga, and Chuanxiong. It is easy to metabolize and can cross the blood-brain barrier to enter the hippocampus. The antidepressant effects of ferulic acid are related to neurotrophic system, monoaminergic nervous system, anti-inflammatory, anti-oxidation, and NMDAR receptor antagonism. In this paper, the antidepressant research of ferulic acid is reviewed, which provides a reference for further exploring the antidepressant mechanism of ferulic acid.