玉屏风颗粒联合头孢克肟治疗儿童反复呼吸道感染的临床研究

Clinical study on Yupingfeng Granules combined with cefixime in treatment of repeated respiratory tract infections in children

目的探讨玉屏风颗粒联合头孢克肟颗治疗儿童反复呼吸道感染的临床疗效。方法选取2016年8月—2017年10月天津市第一中心医院收治的反复呼吸道感染患儿96例为研究对象,采用随机数字表法将96例患儿分为对照组和治疗组,每组各48例。对照组患儿口服头孢克肟颗粒,3.0 mg/kg,2次/d。治疗组患儿在对照组治疗的基础上口服玉屏风颗粒,<2岁的患儿2.5g/次,≥2岁的患儿5g/次,3次/d。两组患儿均连续治疗5d。观察两组的临床疗效,比较两组的炎性因子水平。结果治疗后,对照组、治疗组的总有效率分别为72.92%、91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-5(IL-5)、白细胞介素-4(IL-4)、降钙素原(PCT)、半胱氨酰白三烯(CysLTs)水平均较治疗前降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患儿的炎性因子水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论玉屏风颗粒联合头孢克肟颗粒治疗儿童反复呼吸道感染具有较好的临床疗效,能减轻炎症反应,安全性较高,具有一定的临床推广应用价值。

Objective To explore the effect of Yupingfeng Granules combined with Cefixime Granules in treatment of repeated respiratory tract infections in children.Methods Children(96 cases)with repeated respiratory tract infections in Tianjin First Central Hospital from August 2016 to October 2017 were randomly divided into control and treatment groups,and each group had 48 cases.Patients in the control group were po administered with Cefixime Granules 3.0 mg/kg,twice daily.Patients in the treatment group were po administered with Yupingfeng Granules on the basis of the control group,less than 2 years old with 2.5 g/time,and more than2 years old with 5 g/time,three times daily.Patients in two groups were treated for 5 d.After treatment,the clinical efficacies were evaluated,and inflammatory factor levels in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were 72.92%and 91.67%,respectively,and there was difference between two groups(P<0.05).After treatment,the levels of IFN-γ,TNF-α,IL-5,IL-4,PCT,and CysLTs in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the inflammatory factor levels in the treatment group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).Conclusion Yupingfeng Granules combined with Cefixime Granule has clinical curative effect in treatment of repeated respiratory tract infections in children,can alleviate inflammation reaction,with good safety,which has a certain clinical application value.