复方木尼孜其颗粒联合甲硝唑凝胶治疗玫瑰痤疮的疗效观察

Clinical observation of Compound Muniziqi Granules combined with Metronidazole Gels in treatment of rosacea

目的探讨复方木尼孜其颗粒联合甲硝唑凝胶治疗玫瑰痤疮的临床疗效。方法选取2017年5月—2018年5月三峡大学人民医院收治的112例玫瑰痤疮患者为研究对象,将所有患者随机分为对照组和治疗组,每组各56例。对照组患者于患处涂擦甲硝唑凝胶,2次/d。治疗组在对照组的基础上口服复方木尼孜其颗粒,6 g/次,3次/d。两组患者持续治疗6周。观察两组的临床疗效,比较两组的临床症状积分、痤疮特异性生活质量问卷(Acne-QOL)积分。结果治疗后,对照组和治疗组的总有效率分别为83.93%、94.64%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者非暂时性红斑积分、阵发性潮红积分、毛细血管扩张积分、丘疹及脓疱积分均明显降低,与治疗前相比呈显著性差异(P<0.05);并且治疗后治疗组各症状积分明显低于对照组,组间差异显著(P<0.05)。治疗后,两组患者Acne-QOL积分均显著升高,与治疗前相比呈显著性差异(P<0.05);并且治疗后治疗组Acne-QOL积分明显高于对照组,组间差异显著(P<0.05)。结论复方木尼孜其颗粒联合甲硝唑凝胶治疗玫瑰痤疮具有较好的临床疗效,可改善患者的临床症状,提高生活质量,安全性高,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Compound Muniziqi Granules combined with Metronidazole Gels in treatment of rosacea.Methods Patients(112 cases)with rosacea in People’s Hospital of Three Gorges University from May 2017 to May 2018 were randomly divided into control and treatment groups,and each group had 56 cases.Patients in the control group were rubbed the affected area with Metronidazole Gels,twice daily.Patients in the treatment group were po administered with Compound Muniziqi Granules on the basis of the control group,6 g/time,three times daily.Patients in two groups were treated for 6 weeks.After treatment,the clinical efficacies were evaluated,and clinical symptom scores and Acne-QOL scores in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were 83.93%and 94.64%,respectively,and there was difference between two groups(P<0.05).After treatment,non-temporary erythema scores,paroxysmal flushing scores,telangiectasia scores,papules and pustules scores in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the observational indexes in the treatment group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).After treatment,Acne-QOL scores in two groups were significantly increased,and the difference was statistically significant in the same group(P<0.05).And the Acne-QOL score in the treatment group was significantly higher than that in the control group,with significant difference between two groups(P<0.05).Conclusion Compound Muniziqi Granules combined with Metronidazole Gels has clinical curative effect in treatment of rosacea,can improve the clinical symptoms and quality of life of patients,with good safety,which has a certain clinical application value.