人血清抵抗素水平与体脂含量和血糖及血压的相关性研究

The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure

目的 了解高血压病患者血清抵抗素浓度 ,探讨血清抵抗素水平和体脂含量、血糖及血压的关系。方法 酶免疫测定法检测 71例高血压病患者 (男 33例 ,女 38例 )的空腹血清抵抗素浓度 ;口服葡萄糖耐量试验 (OGTT)和胰岛素释放试验 ,测定血浆葡萄糖浓度和血清胰岛素浓度 ,计算葡萄糖曲线下面积 (AUCG)和OGTT开始 30min胰岛素和血糖变化的比值 (ΔI30 /ΔG30 ) ,根据Cederholm公式计算胰岛素敏感指数 (ISI) ;测量收缩压 (SBP)、舒张压 (DBP)、身高、体重、腰围、臀围 ,计算体重指数(BMI)、体内脂肪百分比 (BF % )及腰围 /臀围比 (WHR)。结果 相关分析显示空腹血清抵抗素浓度男性 (2 3μg/L± 9μg/L)低于女性 (2 7μg/L± 11μg/L)与AUCG(r=0 380 ,P <0 0 0 1)及BF % (r=0 35 3 ,P<0 0 1)呈显著正相关 ,与ISI(r=- 0 2 42 ,P <0 0 5 )及ΔI30 /G30 (r=- 0 2 98,P <0 0 5 )呈显著负相关 ,与SBP、DBP、BMI及WHR无相关 ;较正年龄和BMI后偏相关分析显示空腹血清抵抗素浓度与AUCG(r=0 2 6 8,P <0 0 5 )仍呈显著正相关 ,与ΔI30 /ΔG30 (r=- 0 2 47,P <0 0 5 )仍呈显著负相关 ,与ISI无相关 ;多元逐步回归分析表明抵抗素浓度是影响血糖的独立因素。结论 血清抵抗素浓度与BF %及血糖浓度的相关性提示抵?

Objective To investigate serum resistin concentration in essential hypertension patients and the relationship between serum resistin level and body fat content, plasma glucose concentration, and blood pressure. Methods Fasting serum resistin concentrations were measured with enzyme immunoassay in 71 cases (including 33 men and 38 women), and oral glucose tolerance test and insulin release test were performed in all cases for calculating glucose area under the curve (AUC G) , the ratio of change in insulin to change in glucose during the first 30 min after glucose ingestion(ΔI 30/ΔG 30) and insulin sensitivity index (ISI) according to Cederholm′s formula. Systolic pressure (SBP), diastolic pressure(DBP), height, body weight, waist circumference and hip circumference were measured to calculate body mass index (BMI), body fat percentage (BF%) and waist-hip ratio (WHR). Results Pearson analysis showed that fasting serum resistin concentrations were correlated with AUC G (r=0.380,P<0.001), BF% (r=0.353, P<0.01), ISI (r=-0.242, P<0.05) and ΔI 30/ΔG 30(r=-0.298, P<0.05), but not correlated with SBP, DBP, BMI and WHR. After adjustment for age and BMI, partial correlation analysis showed that fasting serum resistin concentrations were correlated with AUC G (r=0.268,P<0.05), ΔI 30/ΔG 30 (r=-0.247, P<0.05)and not correlated with ISI. A stepwise multiple linear regression analysis showed that resisitin was a significant independent predictor of AUC G. Conclusion The strong correlation between fasting serum resistin levels and AUC G, and BF% suggests a possibility that resistin link obesity to diabetes in humans.