应用于内窥镜的聚酰亚胺涂覆双包层光纤束（英文）

Polyimide-coated fiber-optic bundle comprising double clad fibers for endoscopy

本文研究了一种适用于临床前研究的小型化(<0.4mm)、低成本纤维束内窥镜装置。该装置包含有一个渐变折射率(GRIN)透镜,它安装在光纤图像引导器的近端。提出了一种简化、低成本的装置连接方案,并讨论了可应用的连接方案。装置中使用的纤维束表面包覆有聚酰亚胺,其在长期和短期植入时都具有生物相容性。最终制备的装置能够承受化学清洗、消毒和高压灭菌,满足普通实验室和临床程序的需求,并且对整体性能有较小的影响。为了验证纤维束的成像质量,本文使用标准测试靶标和荧光微球进行评估。结果表明,光纤与自发荧光之间的串扰对成像质量的影响很小,该纤维束无需复杂光路和激光扫描即可实现荧光样品分子级的分辨率。

A miniaturized(<0.4 mm),low-cost fiber bundle based endoscope suitable for pre-clinical research was presented.The device incorporates a Gradient-Index(GRIN)lens bonded to the proximal end of a fiber-optic image guide.Further,a simplified,low-cost connectorization method was proposed and connectorization for alternative applications was discussed.The fiber bundle was coated with polyimide which was bio-compatible for both long-and short-term implantation.In keeping with common laboratory and clinical procedures,the finished assembly allows for chemical cleaning,disinfection and autoclave sterilization with negligible impact on the overall performance of the device.The performance was evaluated by using standard test targets for white light as well as fluorescent micro-spheres to verify image quality.The results show that the effects of crosstalk between fibers and autofluroescence have a minimal impact on image quality.The fiber bundle assembly is able to resolve fluorescent samples at cellular resolution without the need for a complex optical path or laser scanning mechanism.