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HIF-1在肿瘤形成中的作用及有氧运动对肿瘤的防治机制 被引量：7

The Role of Hypoxia-inducible Factor 1 on Tumorigenesis and the Mechanisms of Aerobic Exercise for Tumor Treatment and Prevention
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摘要 长期不运动会导致机体血液循环减慢,组织细胞处于慢性缺氧状态,导致细胞对缺氧微环境发生适应性应激反应,缺氧诱导因子表达增加,激活下游信号传导通路,进而与肿瘤的发生密切相关。有氧运动可加速血液循环,提高组织细胞微环境含氧量,加速缺氧诱导因子在有氧状态下降解,抑制癌症相关信号传导通路。适度的有氧运动可减少体内缺氧诱导因子,对癌症的治疗和预防有不可忽视的作用。 It would lead to slow down blood circulation if you hardly do ever exercises. So in this time, the histiocytes of your body are in the state of hypoxia, then the histiocytes course adaptive stress response to hypoxia microenvironment, the expression of hypoxia-inducible factor will be increased to activate downstream signal transduction pathway, which is related to tumorigenesis. Aerobic exercise can help accelerate blood circulation to improve tissue oxygen supply, speed up hypoxia-inducible factor degradation, inhibit the signal transduction pathway which is related to tumorigenesis. Thereby, moderate aerobic exercise plays an unnegligible role of cancer treatment and prevention by reducing hypoxia-inducible factor in vivo.
作者 罗昊翔
机构地区 黔西南民族职业技术学院医药系
出处 《基因组学与应用生物学》 CAS CSCD 北大核心 2015年第12期2570-2574,共5页 Genomics and Applied Biology
基金 贵州省科技厅科学技术基金项目(黔科合J字[2013]2268号)资助
关键词 缺氧诱导因子 肿瘤形成 信号传导 有氧运动 Hypoxia-inducible factor-1,Tumorigenesis,Signal transduction,Aerobic exercise
分类号 R87 [医药卫生—运动医学]
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基因组学与应用生物学
2015年 第12期

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