期刊文献+

KISS-1/GPR54基因在猪繁育性能中的作用概述 被引量:2

The Role in Reproduction of KISS-1/GPR54 Gene in Pigs
原文传递
导出
摘要 KISS-1和GPR54(Kiss-1受体)基因共同作用组成KISS-1/GPR54系统,参与HPGA启动青春期,调节下丘脑分泌Gn RH,并刺激垂体门脉系统分泌LH、FSH对性腺产生作用,刺激雌激素、睾酮等激素合成,进而促使卵子和精子的产生,使个体具备生殖能力,在生殖中起关键调控作用。该文章对这两个基因在猪的繁育性能中的作用进行简述,旨在探讨和挖掘影响猪繁育的遗传机理及作用,为更有效地提高猪场产量及优良繁育猪种的选育提供参考依据。 KISS-1/GPR54 system formed by KISS-1 and GPR54(KISS-1, sreceptor) genes, participates in the HPGA activity to switch on the puberty of animals, regulates Gn RH secretion from the hypothalamus, and stimulates the pituitary system to secrete the LH and FSH to influence the gonads, promotes the synthesis of hormones such as estrogen and testosterone, produces eggs and sperm, and finally leads to an individual with reproductive capacity. Therefore, this system plays a key regulatory role in the reproduction of animal. In this paper, we briefly reviewed the role of KISS-1/GPR54 gene in the reproductive capacity of pigs. The content of this paper could provide some help in exploring the genetic mechanism of reproduction regulation in pigs, and also could provide a reference for improving the production of pig farm and the breeding projects of excellent pigs.
出处 《基因组学与应用生物学》 CAS CSCD 北大核心 2015年第12期2763-2767,共5页 Genomics and Applied Biology
基金 中央级公益性科研院所基本科研业务专项(中国热带农业科学院热带作物品种资源研究所)1630032013001和1630032015002共同资助
关键词 KISS-1 GPR54 繁育性能 Pig,KISS-1,GPR54,Reproduction
  • 相关文献

参考文献26

  • 1Waljit S Dhillo,Kevin G Murphy,Stephen R Bloom.??The neuroendocrine physiology of kisspeptin in the human(J)Reviews in Endocrine and Metabolic Disorders . 2007 (1)
  • 2J. T. Smith,I. J. Clarke.??Kisspeptin expression in the brain: Catalyst for the initiation of puberty(J)Reviews in Endocrine and Metabolic Disorders . 2007 (1)
  • 3Florent G. Revel,Michel Saboureau,Mireille Masson-Pévet,Paul Pévet,Jens D. Mikkelsen,Valérie Simonneaux.Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters[J]. Current Biology . 2006 (17)
  • 4M.L. Gottsch,D.K. Clifton,R.A. Steiner.??Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis(J)Molecular and Cellular Endocrinology . 2006
  • 5Ieuan A. Hughes,Mekalai Kumanan.??A wider perspective on puberty(J)Molecular and Cellular Endocrinology . 2006
  • 6Sandrine Funes,Joseph A Hedrick,Galya Vassileva,Lisa Markowitz,Susan Abbondanzo,Andrei Golovko,Shijun Yang,Frederick J Monsma,Eric L Gustafson.The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system[J]. Biochemical and Biophysical Research Communications . 2003 (4)
  • 7Thompson Emily L,Murphy Kevin G,Patterson Michael,Bewick Gavin A,Stamp Gordon W H,Curtis Annette E,Cooke Jennifer H,Jethwa Preeti H,Todd Jeannie F,Ghatei Mohammad A,Bloom Stephen R.Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. American journal of physiology. Endocrinology and metabolism . 2006
  • 8Castellano J M,Navarro V M,Fernández-Fernández R,Nogueiras R,Tovar S,Roa J,Vazquez M J,Vigo E,Casanueva F F,Aguilar E,Pinilla L,Dieguez C,Tena-Sempere M.Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. The Journal of Endocrinology . 2005
  • 9Dungan Heather M,Clifton Donald K,Steiner Robert A.Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. The Journal of Endocrinology . 2005
  • 10Finn P D,Cunningham M J,Pau K Y,et al.The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey. The Journal of Endocrinology . 1998

二级参考文献118

  • 1王雪松,汤军,崔毓桂.新的生殖激素调控系统——KiSS-1/GPR54[J].国外医学(计划生育.生殖健康分册),2006,25(4):197-199. 被引量:8
  • 2甘晓红,洪华珠,肖君华.GPR54及其配体与青春期发育[J].国际内分泌代谢杂志,2006,26(6):424-426. 被引量:7
  • 3Muir AI,Chamberlain L,Elshourbagy NA,et al. AXOR12,a novel human G protein - coupled receptor, activated by the peptide KISS - 1 [J]. J Biol Chem,2001,276(31 ) :28969 -28975.
  • 4Kotani M , Detheux M , Vandenbogaerde A , et al. The metastasis suppressor gene KiSS - 1 encodes kisspeptin. - s, the nattrral ligands of the orphan Gprotein -coupled receptor GPR54[J]. J Biol Chem, 2001,276 (37) :34631- 34636.
  • 5Ohtaki T , Shintani Y, Honda S , et al. Metastasis suppressor gene KiSS - 1 encodes peptide ligand of a G - prot - ein - coupled receptor [J]. Nature, 2001, 411 (6837) :613-617.
  • 6Clements MK, McDonald TP , Wang R , et al. FMRF amiderelated neuropeptides are agonists of the orphan G - protein - coupled receptor GPR54 [ J ] . Biochem Biophys Res Commun, 2001, 284 (5) : 1189 ~ 1193.
  • 7Dhar DK, Naora H , Kubota H , et al. Downregulation of KiSS - 1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma [J]. Int J Cancer, 2004 , 111(6) : 868-872.
  • 8Irwig MS, Fraley GS, Smith JT, et al. Kisspeptin activation of gonadotropin releasing hormone neurons and regu - lation of KiSS - 1 mRNA in the male rat [ J ]. Neuroendocrinology, 2004,80 (4) :264 -272.
  • 9Yasuko Teraoa, Satoshi Kumano, et al. Expression of KiSS - 1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta[J]. Biochimica et Biophysica Acta, 2004, 1678:102 - 110.
  • 10Dr K. G. Murphy, Kisspeptins: Regulators of Metastasis and the Hypothalamic - Pituitary - Gonadal Axis [ J ]. Journal of Neuroendocrinology,2005, 17,519 - 525.

共引文献31

同被引文献17

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部