糖电解质运动饮料对泌尿系结石危险因素不产生影响

Carbohydrate-electrolyte Sports Drink does not Affect the Risk Factors of Urinary Calculi

为了评估补充碳水化合物-电解质的运动饮料(佳得乐)对泌尿系结石危险因素的影响,本试验对32名正常志愿者(15名男性, 17名女性)和28名高钙化结石形成者(15名男性, 13名女性)进行由3个研究阶段组成的4周前瞻性交叉研究。在第一阶段中,受试者进行标准化的预防结石饮食。在第二阶段中,受试者每天摄入2 L佳得乐,然后进行7 d的清除期。在第三阶段中,受试者每天摄取2 L水,在三个阶段的最后一天,分析24 h尿液采集和血液样本的结石危险因素。使用重复测量的方差分析和配对t检验来测试组内和组间差异。佳得乐消耗后尿液危险因素的变化显示,正常受试者和结石形成者之间没有统计学显著性差异,但两组均发生了主体间变异。两组中的佳得乐消耗使尿液p H (p=0.007)、尿中氯化物(p=0.036)和尿钠(p=0.009)增加,而使尿钾(p=0.041)和尿中尿酸(p=0.022)降低。与饮水和基线相比,佳得乐消耗后的尿钙和柠檬酸盐无显著变化。综上所述,与水和基线相比,佳得乐可增加尿钠和氯化物水平,但泌尿参数在正常的范围内,由于尿钙变化没有显著差异,因此这种变化无临床意义,所以佳得乐的消耗不会增加或减少泌尿系结石危险因素。

In order to evaluate the effects of consumption of carbohydrate-electrolyte sports drinks(Gatorade)on risk factors of urinary calculi,in this study,32 normal volunteers(15 males,17 females)and 28 hypercalcite-formers(15 males,13 females)participated in a 4-week prospective crossover study consisting of 3 study phases.In the first stage,the subjects performed a standardized stone-prevention diet.In the second stage,the subjects ingested 2 liters of Gatorade per day and then performed a 7-day washout period.In the third phase,the subjects ingested 2 liters of water daily.On the last day of each of the three phases,the risk factors for stone formation in the 24-hour urine collection and blood samples were analyzed.Intra-group and inter-group differences were tested using repeated measures analysis of variance and paired t-tests.Changes of the risk factors for urine after Gatorade consumption showed no statistically significant differences between normal subjects and stone-formers.However,inter-subject variability occurred in both groups.Gatorade consumption in both groups resulted in an increase in urine pH(p=0.007),urinary chloride(p=0.036),and urinary sodium(p=0.009),whereas urinary potassium(p=0.041)and urine uric acid(p=0.022)decreased.There was no significant change in urinary calcium and citrate after Gatorade consumption compared to drinking water and baseline.In summary,Gatorade could increase urinary sodium and chloride levels compared to water and baseline,but urinary parameters were within the normal range,and since urinary calcium had no obvio us difference,this change had no clinical significance.Therefore,the consumption of Gatorade could not increase or decrease the risk factors for urinary calculi.