摘要
采用Feeney′s方法制备了鼠脑创伤模型,利用太赫兹波透射式成像系统对鼠脑的组织切片进行成像检测,结果表明:鼠脑创伤区域相比于正常区域具有更低的透过率。采用三维重构技术实现了鼠脑的三维建模,该模型可以清楚地反映鼠脑内部创伤区域的空间分布。基于太赫兹波多深度切片成像的三维重建技术在生物医学精确诊断方面具有巨大的应用潜力。
The rat brain trauma model is established with Feeney′s method.The rat brain tissue slices are imaged with the terahertz transmission imaging system,which shows that the rat brain traumatic region has lower transmittance than the normal region.The three-dimensional modeling of rat brain is realized by the three-dimensional reconstruction technique.The model clearly reflects the spatial distribution of the traumatic region inside the rat brain.This study suggests that the three-dimensional reconstruction technique based on terahertz multi-depth slices imaging has great potential in the precise and accurate biomedical diagnosis.
作者
王与烨
陈霖宇
徐德刚
陈图南
冯华
姚建铨
Wang Yuye;Chen Linyu;Xu Degang;Chen Tunan;Feng Hua;Yao Jianquan(Institute of Laser and Optoelectronics,School of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,China;Key Laboratory of Opto-Electronics Information Technology(Ministry of Education),Tianjin University,Tianjin 300072,China;Institute of Neurosurgery,the First Hospital Affiliated to Army Medical University,Chongqing 400038,China)
出处
《光学学报》
EI
CAS
CSCD
北大核心
2019年第3期314-319,共6页
Acta Optica Sinica
基金
973计划(2015CB755403
2014CB339802)
国家重点研发计划(2016YFC0101001)
国家自然科学基金(61775160
61771332
61471257)
中国博士后科学基金特别资助(2016M602954)
重庆市博士后科研项目特别资助(Xm2016021)
重庆西南医院生物强院科技创新计划(SWH2016LHJC04
SWH2016LHJC01)
关键词
医用光学
生物医学成像
外伤性脑损伤
太赫兹波
三维重建
medical optics
biomedical imaging
traumatic brain injury
terahertz wave
three-dimensional reconstruction
