红霉素联合四磨汤口服液治疗早产儿喂养不耐受的临床效果研究

Clinical effect of erythromycin combined with Simotang oral liquid on feeding intolerance of premature infants

目的:探讨红霉素联合四磨汤口服液治疗早产儿喂养不耐受的临床效果。方法:选取2016年1月至2018年10月在广西医科大学第五附属医院新生儿科住院的240例早产儿,按随机数字表法分为6组:A组(常规治疗)、B组(常规治疗+综合护理)、C组(常规治疗+综合护理+四磨汤口服液)、D组(常规治疗+综合护理+小剂量红霉素)、E组(常规治疗+综合护理+吗叮啉)和F组(常规治疗+综合护理+小剂量红霉素+四磨汤口服液),每组40例。比较6组临床疗效、呕吐消失时间、腹胀消失时间和静脉营养应用时间,并观察不良反应发生情况。结果:B组、C组、D组、E组和F组呕吐消失时间、腹胀消失时间和静脉营养应用时间分别与A组比较,差异均有统计学意义(均P<0.05)。D组、E组、F组呕吐消失时间明显短于B组与C组(P<0.05),B组与C组比较差异无统计学意义(P>0.05),D组、E组、F组间比较差异亦无统计学意义(P>0.05)。F组腹胀消失时间、静脉营养应用时间均明显短于其他各组(均P<0.05),C组、D组、E组间比较差异无统计学意义(P>0.05)。所有早产儿均无明显不良反应发生。结论:四磨汤口服液、小剂量红霉素或吗叮啉均能有效治疗早产儿喂养不耐受,红霉素联合四磨汤口服液的疗效更佳。

Objective:To explore the clinical effect of erythromycin combined with Simotang oral liquid in the treatment of feeding intolerance of premature infants.Methods:From January 2016 to October 2018,240 premature infants in our hospital were selected and randomly divided into six groups(n=40):group A,B,C,D and E.All infants received conventional treatment.Infants in group B received comprehensive nursing care,infants in group C received comprehensive nursing and Simotang oral liquid,infants in group D received comprehensive nursing care and low dose of erythromycin,those in group E received comprehensive nursing care and morpholine,and those in group F received comprehensive nursing care,low dose of erythromycin and Simotang oral liquid.The vomiting disappearance time,abdominal distension disappearance time,intravenous nutrition application time,and adverse reactions were observed.Results:The vomiting disappearance time,abdominal distension disappearance time and intravenous nutrition application time in group B,C,D,E and F were shorter than those in group A(P<0.05).The time of vomiting disappearance in group D,E and F was significantly shorter than that in group B and C(P<0.05).There was no statistical difference among group D,E and F or between group B and C(P>0.05).The time of abdominal distension and parenteral nutrition in group F was significantly shorter than that in other groups(P<0.05),and no significant difference was noted among group C,D and E(P>0.05).No obvious adverse reactions were found in all preterm infants.Conclusion:Simotang oral liquid,low dose of erythromycin or morpholine was effective in the treatment of feeding intolerance in premature infants,and the effect of erythromycin combined with Simotang was better.