颈髓损伤患者血液流变学及抗氧化能力的临床观察

Clinical study of the hemorheologic and antioxidization characteristics in patients with cervical spinal cord injury

目的 观察颈髓损伤患者血液流变学及机体抗氧化能力的变化并探讨其临床意义。方法 40例颈髓损伤患者治疗前后根据脊髓损伤的神经和功能分类标准 ,评定脊髓损伤的程度及疗效。治疗前后检测血液流变学及超氧化物歧化酶 (SOD)和丙二醛 (MDA)水平 ,与对照组比较 ,观察颈髓损伤患者血液流变学及抗氧化能力的变化。结果 颈髓损伤患者治疗前血液粘皮增高 ,表现为全血粘度高低切变值、血浆粘皮及血沉均高于对照组。血清SOD活力降低且MDA含量增高 ,提示机体抗氧化能力下降。治疗后运动及感觉功能评分均有明显改善 ,血液粘度下降且抗氧化能力提高。结论 颈髓损伤可出现血液粘皮增尚及抗氧化能力下降 。

Objective To observe the hemorheologic and antioxidization characteristics in cervical spinal cord injury patients and explore their underlying clinical significance. Methods There were 40 cases with cervical spinal cord injury in this study. Based on the neural and functional classification standard of spinal cord injury, the degree of damage and the clinical theraputic effect were assessed. The hemorheologic features and the level of superoxide dismutase(SOD) and malondialdehyde (MDA)in blood serum were measured before treatment and 1 month later. By comparing with the control group, the changes of the hemorheologic and antioxidization characteristics in cervical spinal cord injury patients were observed. Results The blood viscosity in patients with cervical spinal cord injury was increased, the level of SOD was decreased and that of MDA increased. Compared with the control group, the whole blood viscosity shear value and plasma viscosity were increased in the patient group. After rehabilitation treatment, the sensory and motor functions in the three groups were all improved remarkably. In addition, the blood viscosity was decreased and the antioxidization power increased. Conclusion The patients with cervical spinal cord injury could have high blood viscosity and decreased antioxidization power which should be taken into account in treatment.