非亲缘非清髓造血干细胞移植成功治疗急性淋巴细胞白血病首例报告

NONMYELOABLATIVE ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FROM UNRELATED DONOR FOR TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA:THE FIRST CASE REPORT

为探讨非亲缘非清髓异基因造血干细胞移植 (URD NAPBSCT)在治疗急性白血病中 (AL)的作用 ,1例HLA完全相合的急性淋巴细胞白血病病人接受了URD NAPBSCT治疗。结果病人顺利度过造血抑制期并获得完全性植入 ,移植后发生了皮肤Ⅱ度GVHD和间质性肺炎 ,经治疗后痊愈。结果初步表明 ,URD NAPBSCT较简便安全 ,可为急性白血病提供新的有效治疗手段。

The purpose of this study was to investigate the clinical efficacy against acute leukemia by transplantation of nonmyeloablative allogeneic peripheral blood stem cells from unrelated donor (URD NAPBSCT). One patient with acute lymphoblastic leukemia received URD NAPBSCT in our hospital. The donor cells were full engafted, and grade Ⅱ skin aGVHD and interstitial pneumonia were developed. The results showed that URD NAPBSCT is an effective new method for the treatment of acute leukemia.