罂粟碱对于防治脑动脉瘤术后脑血管痉挛的临床研究

EFFECT OF PAPAVERINE ON CEREBRAL VASOSPASM FOLLOWING CEREBRAL ANEURYSM OPERATION

通过采用罂粟碱的不同给药途径研究比较其对脑血管痉挛 (CVS)的防治效果。将 43例动脉瘤患者随机分成A、B两组 ,A组术中经置入脑池的硅胶管用罂粟碱溶液持续灌洗 ;B组术后使用罂粟碱 3 0mg肌肉注射 ,每日 3次 ,共 1周。结果显示 ,A组防治血管痉挛的效果明显优于B组。

To evaluate the effect of papaverine administered via different routes following cerebral aneurysm operation, 43 cerebral aneurysm patients were divided randomly into two groups: A and B. Patients of group A were placed with a silicagel tube in cerebral ventricle and lavaged repeatedly with papaverine solution during operation and following 3 days after operation, those of group B were intramuscularly injected with papaverine 30mg, 3 times per day,for one week. By analysis of clinical features and TCD data, both A and B could cure cerebral vasospasm, but group A was obviously superior to group B. Our conclusion is that papaverine solution lavaged locally can effectively prevent cerebral vasospasm after cerebral aneurysm operation .