肺炎衣原体感染与心肌梗死、C反应蛋白的相关性研究

The study of relation between the infection of chlamydia pneumoniae and myocardial infarction, C-reactive protein

目的研究肺炎衣原体 (CP)感染与冠心病急性心肌梗死 (AMI)、C反应蛋白 (CRP)的相关性。方法用酶联免疫吸附测定法 (ELISA)对急性心肌梗死急性期组 (AMIA)、急性心肌梗死恢复期组 (AMIR)、陈旧性心肌梗死组 (OMI)、正常对照组 (N)分别进行CP特异性IgG、IgM抗体检测 ;用聚合酶链反应技术 (PCR)对上述检测的IgG阳性标本进行CPDNA检测 ;并检测各组的血CRP水平。结果各病例组IgG阳性率明显高于N组 (P <0 0 5 ) ;AMIA 组IgM阳性率显著高于其余 3组 (P <0 0 5 )。PCR技术检测各组中IgG阳性组CPDNA阳性率很高。IgG阳性与AMI的发生有相关性 ,校正了影响因素后OR =2 0 ,P <0 0 5。AMIA 组中CRP水平明显高于其余 3组 ,有显著性意意义 (P <0 0 5 ) ,而后3组之间无显著性差异 (P >0 0 5 )。AMIA 组、OMI组中显示IgG与CRP有相关性 (r =0 72 76 ,P =0 0 0 0 ;r=0 6 380 ,P =0 0 0 8)。结论CP感染与冠心病急性心肌梗死的发生有关 ,很可能CP急性感染是急性心肌梗死的一个促发因素 ;CP急性感染与ORP水平升高有关 。

Objective To study the relation between the infection of chlamydia pneumoniae (CP) and cute myocardial infarction (AMI) in coronary heart disease (CHD), C reactive protein (CRP). Methods The specific antibodies IgG, IgM against CP were determined in AMIA, AMIR (restoration stage in AMI), OMI (old myocardial infarction) and N (normal) groups by ELISA. The CP DNA was determined in IgG-positive samples by PCR. The levels of CRP were also determined in the groups by ELISA. Results IgG-positive rates in all case groups was significantly higher than the N group ( P <0.05); IgM-positive rate in AMIA group was significantly higher than other groups ( P <0.05). The CP DNA-positive rates by PCR in IgG-positive groups were very high. The positivety of IgG was relation to AMI. The level of CRP in AMIA group was significantly higher than the levels of CRP in the rest groups ( P <0.05), but there were not significant difference in the rest groups. IgG was relation to CRP in AMIA group and OMI group. Conclusions 1. The CP infection is relation to AMI in CHD, and the acute CP infection may be one of inducing factors of AMI. 2. Acute CP infection is relation to the elevation of CRP, and maybe acute CP infection induced the elevation of CRP in patients suffering from AMI.