妊娠期肝内胆汁淤积症对妊娠及分娩结局的影响

The effect of inntrahepatic cholestasis in the pregnancy and labor outcome

目的探讨妊娠期肝内胆汁淤积症 (ICP)对妊娠及分娩结局的影响及中西医治疗ICP的效果。方法以病例对照研究方法分析 2 0 0 0年 1月至 2 0 0 2年 6月共 2 16例ICP ,比较治疗组 10 2例及未治疗组114例效果。结果 2 16例ICP中围产儿死亡 7例 ,占 32 4‰ ,胎儿窘迫率 36 1% ,早产率 17 1% ,新生儿窒息率 4 17%。通过中西医药物治疗及密切监护 ,治疗组较未治疗组围产儿死亡率、胎儿窘迫率降低 ,差异有显著意义 (P <0 0 1)。结论加强高危门诊的产前检查 ,对ICP孕妇做到早发现、早诊断、早治疗 ,动态监测血生化指标、胎儿宫内情况及胎盘功能 ,适时终止妊娠 。

Objective To investigate the effect of intrahepatic cholestasis of pregnancy(ICP)on labor outcome and China-west medicine treated effect of ICP.Methods A contrast analysis was carried out.216 cases of ICP was analysed from Jan,2000 to June,2002.The treatment group was 102 cases and control group 114 cases.Results The perinatal fetal death were 7cases in 216cases(32.4‰).The fetal distress rate was 36.1%.The premature birth rate was 17.1%.Neonate asphyxia rate was 4.17%.The treatment group of perinatal fetal mortality and fetal distress were lower than that in the control group.Conclusion The obsterician should pay more attention to the health care of the pregnant woman with ICP.At the same time that the monitor fetus carefully and deal with labor actively to decrease the perinatal morbidity mortality of the fetus.