红枣醋对慢性酒精肝损伤的保护作用

Protective Effect of Chinese Jujube Vinegar on Alcohol-induced Liver Damage in Mice

以酒精溶液(50%,V/V,10 m L/kg)灌喂小鼠42 d,建立酒精肝损伤模型,研究红枣醋对酒精中毒引起肝损伤的保护作用。结果表明,不同剂量的红枣醋均能显著降低慢性酒精中毒小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性,降低血清甘油三酯(TG)和胆固醇(TC)含量以及肝脏脂质过氧化(LPO)水平,明显改善肝组织肿大;不同剂量的红枣醋均能显著提高慢性酒精中毒小鼠肝脏还原型谷胱甘肽(GSH)水平,提高肝组织总超氧化物酶(T-SOD)、过氧化氢酶(CAT)以及谷胱甘肽过氧化物酶(GSH-Px)活性,保护小鼠肝组织抗氧化系统。肝组织病理检查结果显示,红枣醋能明显改善慢性酒精中毒引起的肝损伤,作用机制与其抑制机体脂质过氧化,增强肝脏抗氧化酶以及非酶抗氧化能力有关。

A mouse model of alcoholic liver injury was established by administering alcohol(50%, V/V, 10 m L/kg) to the mice for 42 days, and the protective effect of Chinese jujube vinegar on alcoholic liver injury in mice was studied. The results showed that different doses of Chinese jujube vinegar significantly reduced the activities of aspartate aminotransferase(AST) and alanine transaminase(ALT), concentrations of triglycerides(TG) and total cholesterol(TC) in the serum and lipid peroxidation(LPO) level in the liver of chronic alcohol-intoxicated mice, and the live tissue enlargement was significantly improved. Meanwhile, different doses of Chinese jujube vinegar significantly increased the glutathione(GSH) content and the activities of total superoxide dismutase(T-SOD), catalase(CAT), and glutathione peroxidase(GSH-Px) and protected the antioxidant system in the liver system of chronically alcohol-intoxicated mice. The results of liver histopathological examination showed that Chinese jujube vinegar may significantly alleviate chronically alcohol-induced liver injury, and the underlying mechanism is related to its inhibitory effect on LPO as well as the enhancement of liver antioxidant enzyme activities and the non-enzymatic antioxidant capacity.