儿童血清1,25二羟维生素D3水平与支气管哮喘发病的关系

Relationship between serum 1,25 dihydroxyvitamin D3 level and bronchial asthma in children

目的:研究儿童血清1,25-二羟维生素D3水平与支气管哮喘发病的相关性,为儿童支气管哮喘的预防和治疗提供依据。方法:以惠州市中医院2015年2月至2015年12月间收治的61例哮喘儿童作为病例组,以113例非哮喘儿童作为对照组,采用调查表收集研究对象的相关信息,并测定血清1,25-二羟维生素D3水平。结果:单因素分析显示支气管哮喘儿童与对照儿童在家族过敏史、日晒时间方面差异有统计学意义(P<0.05);两组对象血清1,25-二羟维生素D3水平分别为(85.43±25.31)nnmol/L和(96.73±28.44)nnmol/L,差异有统计学意义(P<0.05),多因素分析显示,血清1,25-二羟维生素D3水平为支气管哮喘发病的保护因素,血清1,25-二羟维生素D3水平越高,支气管哮喘发病风险越低,OR=0.72(95%CI=0.56~0.92)。结论:血清1,25-二羟维生素D3水平与儿童支气管哮喘发病相关,应适当补充维生素D和增加日晒时间,预防维生素D缺乏。

Objective: To investigate the relationship between serum level of 1,25-dihydroxyvitamin D3 and bronchial asthma in children,so as to provide evidence for the prevention and treatment of bronchial asthma in this patient population.Methods: Included in this study were 61 children( patient group) with asthma and 113 non-asthmatic children( control group) treated in Huizhou Hospital of Traditional Chinese Medicine between February 2015 and December 2015. Questionnaires were used to collect the demographic information of the subjects. Serum level of 1,25-dihydroxyvitamin D3 was detected. Results: Univariate analysis showed statistically significant differences in family history of allergy and sunshine exposure between the asthmatic children and controls. The serum levels of 1,25-dihydroxyvitamin D3 in the two groups were( 85.43±25.31) nnmol/L and( 96.73± 28. 44) nnmol/L,respectively,with statistically significant difference between the two groups. Multivariate analysis showed that serum 1,25-dihydroxyvitamin D3 was protective against the pathogenesis of bronchial asthma. Higher level of serum 1,25-dihydroxyvitamin D3 was associated with lower risk of bronchial asthma( OR= 0.72,95%CI = 0.56 ~ 0.92). Conclusion: Serum 1,25-dihydroxyvitamin D3 levels are correlated with onset of bronchial asthma in children. Vitamin D supplementation and increasing sunshine exposure should be encouraged to prevent vitamin D deficiency.