宁泌泰胶囊联合非那雄胺治疗前列腺电切术后血尿的疗效观察

Effect of Ningmitai capsule and Finasteride on hematuria after transurethral resection of prostate

目的:观察宁泌泰胶囊联合非那雄胺治疗经尿道前列腺电切术(TURP)后血尿的疗效。方法:选取2016年9月至2017年10月茂名市电白区人民医收治的52例TURP术后血尿患者作为研究对象,按照随机数表法分为观察组与对照组,每组各26例。对照组仅给予非那雄胺治疗,观察组采用非那雄胺联合宁泌泰胶囊治疗。比较两组治疗前及治疗1个月后WBC、分泌型免疫球蛋白A(SIg A)等前列腺液常规检测指标,白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)等血清炎性因子的变化;比较两组治疗1个月后良性前列腺增生患者生活质量量表(BPHQLS)、治疗效果及药物不良反应发生情况异。结果:治疗1个月后,两组患者前列腺液WBC与SIg A、血清IL-1β与IL-10水平均较治疗前显著下降(均P<0.05),其中观察组低于同期对照组(均P<0.05)。观察组BPHQLS各项评分及总分均高于对照组(均P<0.05);观察组治疗有效率高于对照组(P<0.05)。两组患者药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:宁泌泰胶囊联合非那雄胺方案对TURP术后血尿治疗效果较为理想,有利于患者预后康复。

Objective: To determine the effect of Ningmitai capsule and Finasteride in the treatment of hematuria after transurethral resection of prostate( TURP). Methods: Fifty-two patients with hematuria after TURP were included as the subjects in the study,and were randomly divided into the study group( n = 26) and control group( n = 26). The control group received the treatment with Finasteride alone,and the study group was treated with Finasteride and Ningmitai capsule. The changes in the routine examination indexes of prostatic fluid[white blood cell count( WBC) and secretory immunoglobulin A( SIg A) ]and serum inflammatory factors[interleukin-1β( IL-1β) and interleukin-10( IL-10) ] were compared between the two groups at the baseline and at 1 month after the treatment. The Qualitfy-of-life Scale for Benign Prostatic Hyperplasia Patient( BPHQLS),efficacy,and occurrence of adverse drug reactions at 1 month after the treatment were compared between the two groups. Results: At 1 month after the treatment,the prostatic fluid WBC and the levels of prostatic fluid SIg A,serum IL-1β and IL-10 in the two groups significantly decreased compared with those at baseline( all P<0.05),and the levels in the study group were significantly lower than those in the contemporary control group( all P<0.05). The item scores and total score of BPHQLS in the study group were higher than those in the control group( all P < 0. 05). The treatment effective rate in the study group was higher than that in the control group( P < 0. 05). There was no statistically significant difference in the incidence of adverse drug reactions between the two groups( P > 0. 05). Conclusion: Ningmitai capsule and Finasteride is ideal for the treatment of hematuria after TURP,which favors the prognosis and rehabilitation of patients.