三龙通栓汤治疗颈动脉粥样硬化斑块的临床观察和护理干预

Clinical observation and nursing intervention of Sanlong Tongshuan decoction in treatment of carotid atherosclerotic plaque

目的:探讨三龙通栓汤治疗颈动脉粥样硬化斑块的临床疗效,并总结治疗期间相应护理措施的干预。方法:以本院2014年4月1日至2016年4月1日间门诊及住院的60例颈动脉粥样硬化斑块患者作为此次研究对象,按照完全随机数表法分为对照组与治疗组,2组各30例,均给予西药常规治疗,治疗组加口服自拟三龙通栓汤和护理干预,观察2组患者的临床疗效(颈动脉斑块的大小)及不良反应。结果:治疗组总有效率明显高于对照组(P<0.05)。治疗后两组Crouse积分、IMT、斑块面积、CCAD以及不稳定斑块数目对比均具有统计学意义(P<0.05)。治疗后治疗组TC、TG、HDL-C、LDL-C等指标较对照组好转程度更佳(P<0.05)。治疗后两组均未发生严重不良反应,仅对照组出现1例恶心、呕吐现象,经休息与对症处理后并无大碍。结论:在常规西药治疗的基础上加用三龙通栓汤可使颈动脉粥样硬化的程度得到有效的控制,疗效显著,用药安全性高,患者易于耐受,同时配合有效的护理干预,提高患者依从性,有助于预防心脑血管意外的发生。

Objective:To investigate the clinical effect of Sanlong Tongshuan decoction in the treatment of carotid atherosclerotic plaque,and to summarize the corresponding nursing interventions during the treatment.Methods:Sixty patients with carotid atherosclerotic plaque who visited our outpatient department or stayed in our hospital between April 1,2014 and April 1,2016 were included as the subjects in the study.All patients were randomly divided into the control group and treatment group(n=30 each).Both groups were given conventional Western medicine.In addition,the treatment group received oral self-made Sanlong Tongshuan decoction and nursing intervention.The clinical effect(size of carotid plaque) and adverse reactions were determined in the two groups.Results:The total effective rate in the treatment group was significantly higher than that in the control group(P<0.05).There were statistical significance in the Crouse score,intima-media thickness(IMT),plaque area,common carotid artery diameter(CCAD) and numbers of unstable plaque between the two groups after the treatment.After the treatment,the improvement of TC,TG,HDL-C,LDL-C,and other indicators in the treatment group were better than those in the control group(P<0.05).No serious adverse reactions occurred in the two groups after the treatment.Only one patient developed nausea and vomiting in the control group,but recovered after rest and symptomatic treatment.Conclusion:The addition of Sanlong Tongshuan decoction to the treatment of conventional Western medicine can effectively control the degree of carotid atherosclerosis with significant efficacy and good safety,and is well-tolerated.Meanwhile,the combination with effective nursing intervention can improve patient compliance,which favors the prevention of cardiovascular and cerebrovascular events.