儿童精神分裂症脑脊液酪氨酸、色氨酸研究

Determination of tyrosine and tryptophane in cerebrospinal fluid of childhood schizophrenics

目的 :了解儿童精神分裂症患者脑脊液 (CSF)中酪氨酸与色氨酸的改变 ,以探讨其发病机理。 方法 :用反相高效液相色谱法测定 16例儿童精神分裂症患儿与对照组儿童脑脊液中酪氨酸和色氨酸的浓度。 结果 :儿童精神分裂症患者CSF中酪氨酸的浓度明显高于对照组。色氨酸的浓度两组无明显差异。 结论 :儿童精神分裂症患者CSF中酪氨酸浓度升高 。

Objective:To understand the changes of tyrosine and trytophane in cerebrospinal fluid (CSF) of childhood schizophrenics. Method:By means of reverse phase and high performance liquid chromatography (HPLC),the tyrosine and tryptophane were determined in CSF of 16 cases with childhood schizophrenia and 11 control cases of childhood appendicitis. Results: The contents of tyrosine were obviously higher than that of controls,then there was no significant difference in the levels of tryptophane between the two groups. Conclusion:It seems that tyrosine participate in pathogenesis of childhood schizophrenia.