溴化铜对芳基烷基酮的选择性溴化反应研究

Bromination of alkylaryl ketone with cupric bromide

研究溴化铜对苯丙酮、间 氯苯丙酮、6 甲氧基 2 丙酰基萘、6 甲氧基 2 乙酰基萘、对 甲氧基苯乙酮和苯乙酮等芳基烷基酮的α 溴化反应。在乙醇或乙酸乙酯 氯仿混合溶剂中 ,溴化铜对芳基丙酮 (苯丙酮、间 氯苯丙酮和 6 甲氧基 2 丙酰基萘 )溴化 ,高收率、高选择性地得到α 溴化产物。芳基乙酮 (6 甲氧基 2 乙酰基萘、对 甲氧基苯乙酮和苯乙酮 )的溴化铜溴化 ,在乙醇中反应 ,选择性得到α

Propiophenone,3 chloro propiophenone and 6 methoxy 2 propionyl naphthane were brominated with cupric bromide in EtOH or AcOEt/CHCl 3,to give α brominated products in 94%～97% yields.6 Methoxy 2 acetylnaphthane,4 methoxyacetophenone and acetophenone were brominated with cupric bromide in EtOH,to give α brominated products in 70%～93% yields.The α brominated products of the alkylaryl ketone were very important intermediates in the field of medicine,pesticide and organic synthesis.