盐酸瑞芬太尼的合成

Synthesis of remifentanil hydrochloride

以 1 苄基 4 哌啶酮为起始原料 ,经Strecker反应、水解、酯化、丙酰化、脱苄基、Micheal加成及成盐反应合成了新型麻醉性镇痛药盐酸瑞芬太尼 ,总收率 7 5 %。

A new potent and ultra short acting narcotic analgesic remifentanil hydrochloride was prepared from N benzyl 4 piperidinone through the Strecker reaction,hydrolysis,propionylation,debenzylation and the Micheal additive reaction in 7 5% total yield.