以国产紫杉醇为主治疗晚期肺癌31例

Domestic paclitaxel-based regimens in the treatment of 31 patients with advanced lung cancer

目的 评价以紫杉醇为主的化疗方案治疗晚期肺癌的疗效和毒副反应。方法 紫杉醇 13 5～175mg/m2 ,第 1天给药 ,2 1天重复 ;或紫杉醇 45～ 70mg/m2 ,第 1、8、15天给药 ,2 1天或 2 8天重复。分别与铂类、异环磷酰胺联合治疗 3 1例晚期非小细胞肺癌 (ⅢB期 2例 ,Ⅳ期 2 5例 )、小细胞肺癌 (广泛期 1例 ,局限期 3例 )。结果 可评价疗效者 2 9例 ,无完全缓解病例 ,部分缓解率为 3 1.0 % (9/2 9)。初治、复治者有效率分别为3 8.5 % (5 /3 1)、2 5 .0 % (4 /16) (P =0 .668)。非小细胞肺癌有效率为 2 4.0 % (6/2 5 ) ,小细胞肺癌有效率 3 /4。全组毒性反应主要为血液学毒性 (2 8/3 1,90 .3 % )和恶心 /呕吐 (2 8/3 1,90 .3 % )。结论 以国产紫杉醇为主联合化疗对晚期肺癌有较好疗效 。

Objective To evaluate the efficacy and toxicity of domestic paclitaxel based regimens in the treatment of advanced lung cancer. Methods Domestic paclitaxel 135 175 mg/m 2 on day 1 of a 21 day cycle or 45 70 mg/m 2 on days 1, 8, and 15 of a 21 day or 28 day cycle. The domestic paclitaxel was respectively combined with platinum or ifosfamide to treat patients with non small cell lung cancer (2 cases in stage ⅢB, 25 in stage stage Ⅳ) or small cell lung cancer (1 extensive case, 3 limited cases). Results There were 29 cases to be evaluated, complete response wasn't observed, partial response rate was 31.0% (9/29). The response rate for initial and retreated patients was 38.5% (5/13) and 25.0% (4/16) (P=0.688) respectively. The response rate of non small cell lung cancer was 24.0% (6/25) and small cell lung cancer's was 3/4. The common adverse effects were hematological toxicity (28/31, 90.3%) and nausea/vomiting (28/31, 90.3%). Conclusion Combined chemotherapy including domestic paclitaxel has better curative effect for advanced lung cancer and some tolerable adverse effects.