78例应用抗菌药物继发真菌感染的临床分析

Fungus Infection due to Anti-bacterial Drugs: A Clinical Analysis of 78 Cases

目的 调查抗菌药物继发院内真菌感染的情况 ,加强抗菌药物的合理应用。方法 对 2 0 0 0年出院患者真菌培养阳性病例进行回顾性分析。结果 应用抗菌药物继发真菌感染占同期真菌感染的 6 0 .9% ,白色念珠菌为主要致病菌 ,占 6 0 .6 % ;继发真菌感染多发于老年患者 ,占感染病例的 5 2 .6 % ;感染部位以肺部感染最多 ;诱发真菌感染的药物以第三代头孢菌素类为主。结论 临床选用抗菌药物 ,应以细菌培养和药敏试验为依据 ,减少 3种以上抗菌药物的联合使用 ,防止频繁更换品种和连续长期使用抗菌药物。

OBJECTIVE To investigate the fungus infection caused by the anti bacterial drugs in order to strengthen the rational administration of anti bacterial drugs.METHODS To review and analyse the fungus cultured positive cases among the discharged patients in 2000.RESULTS The fungus infection due to the anti bacterial drugs holds 60.9%. The main pathogenic bacteria are Candida albicans, holding 60.6%, the induced fungus infection patients, which holds 52.6%. The infection sites lie mostly in lungs and the drug induced fungus infection centres on cephalosporins of the third generation.CONCLUSIONS The clinically selected anti bacterial drugs should be based on the bacterial culture and drug susceptibility test, the combined use of more than 3 kinds of anti bacterial drugs should be reduced and frequently changing the medicine and continuing the administration of anti bacterial drugs for a long period of time should be avoided.