摘要
从牛心番荔枝AnnonareticulataL.种子中分得两个番荔素(Annonaceousacetogenin):Squamone(1)和Isoannonareticin(2)。经制备TLC分离,将1和2的乙酰化物1a和2a分离得到两对2位差向异构体:2,4cisSquamonediacetate(1a1),2,4transSquamonediacetate(1a2),2,4cisIsoannonareticindiacetate(2a1)和2,4transIsoannonareticindiacetate(2a2)。其中2,4顺式体的11和21是新的番荔素成分。根据光谱(1H1HCOSY,NOE)数椐分析。
Two annonaceous acetogenins: squamone (1) and isoannonareticin (2) have been isolated from the seeds of Annona reticulata L. (Annonaceae). 1 and 2 were shown to be mixtures of 2epimers by the successful separation of their acetates with preparative TLC, giving: 2,4cissquamone diacetate (1a1), 2,4transsquamone diacetate (1a2), 2,4cisisoannonareticin diacetate (2a1) and 2,4transisoannonareticin diacetate (2a2). The 2,4cissquamone (11) and 2,4transisoannonareticin (21) are new annonaceous acetogenins. Their structures and relative stereochemistry were elucidated on the basis of spectral analysis (1H1H COSY and NOE).
出处
《药学学报》
CAS
CSCD
北大核心
1997年第12期914-919,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
牛心番荔枝
番荔素
化学结构
Annonaceae
Annona reticulata
Acetogenin
2,4cisSquamone
2,4transSquamone
2,4cisIsoannonareticin
2,4transIsoannonareticin